公司自成立以來，推出的技術服務和產品得到了廣大客戶的認可與支持，回顧過往客戶引用“

AtaGenix Laboratories Co., Ltd.(Wuhan), Wuhan, PR China

”發(fā)表的文章，主要集中在免疫、蛋白靶點、癌癥、神經、植物及病毒等領域。普健生物持續(xù)為客戶提供優(yōu)質可信賴的品質技術服務，助力客戶在Nature Communications（Nature子刊）、Molecular Cancer、EBioMedicine（The Lancet子刊）等SCI頂級期刊發(fā)表高分文獻！以下是2023年部分高分文獻展示，更多文獻分享可見官網

協(xié)助客戶發(fā)表文獻

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AtaGenix Laboratories Co., Ltd.(Wuhan), Wuhan, PR China】

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抗體類

A novel polypeptide CAPG-171aa encoded by circCAPG plays a critical role in triple-negative breast cancer

Runjie Song, Peilan Guo, Xin Ren, Lijun Zhou, Peng Li, Nafis A Rahman, S?awomir Wo?czyński, Xiru Li, Yanjun Zhang, Mei Liu, Jiali Liu & Xiangdong Li

PMID：37408008

Epub：2023 Jul 5

Engineered hypermutation adapts cyanobacterial photosynthesis to combined high light and high temperature stress

Huili Sun, Guodong Luan, Yifan Ma, Wenjing Lou, Rongze Chen, Dandan Feng, Shanshan Zhang, Jiahui Sun & Xuefeng Lu

PMID：36871084

Epub：2023 Mar 4

YAP/TEAD1 and β-catenin/LEF1 synergistically induce estrogen receptor α to promote osteogenic differentiation of bone marrow stromal cells

Peiqi Wang, Lingyi Huang, Fan Yang, Wanxi Chen, Ding Bai, Yongwen Guo

PMID：37197086

Epub：2023 May 14

A novel salivary effector, BtE3, is essential for whitefly performance on host plants

Zhengke Peng, Qi Su, Jun Ren, Lixia Tian, Yang Zeng, Yuting Yang, Shaoli Wang, Wen Xie, Qingjun Wu, Zhenyu Li, Youjun Zhang

PMID：36648335

Epub：2023 Mar 28

Potent Therapeutic Strategies for COVID-19 with Single-Domain Antibody Immunoliposomes Neutralizing SARS-CoV-2 and Lip/cGAMP Enhancing Protective Immunity

Yajun Zhou,?Xing Lu,?Xiaoqing Wang,?Tianlei Ying,?Xiangshi Tan

PMID：36835479

Epub：2023 Feb 17

Cuticular competing endogenous RNAs regulate insecticide penetration and resistance in a major agricultural pest

Li-Wei Meng, Guo-Rui Yuan, Meng-Ling Chen, Li-Sha Zheng, Wei Dou, Yu Peng, Wen-Jie Bai, Zhen-Yu Li, John Vontas & Jin-Jun Wang

PMID：37667263

Epub：2023 Sep 5

Phosphorylation of VP1 Mediated by CDK1-Cyclin B1 Facilitates Infectious Bursal Disease Virus Replication

Xifeng Hu,?Zheng Chen, Xiangdong Wu, Zhen Ding, Yu Huang, Qiuling Fu, Zhen Chen,?Huansheng Wu

PMID：36602364

Epub：2023 Jan 31

Flexible Amperometric Immunosensor Based on Colloidal Quantum Dots for Detecting the Myeloperoxidase (MPO) Systemic Inflammation Biomarker

Yanbing Tao,Yunong Zhao,Le Wang,Jing Huang,Yan Chen,Qing Huang,Boxiang Song,Hua-Yao Li,Jianjun Chen,Huan Liu

PMID：36832021

Epub：2023 Feb 10

Review of therapeutic mechanisms and applications based on SARS-CoV-2 neutralizing antibodies

Mingtao Liu,Hui Gan, Zhiman Liang, Li Liu, Qiwen Liu, Yiyin Mai, Huihuang Chen, Baoying Lei, Shangwei Yu, Huihui Chen, Peiyan Zheng, Baoqing Sun

PMID：37007494

Epub：2023 Mar 16

The Additional 15 nt of 5′ UTR in a Novel Recombinant Isolate of Chilli Veinal Mottle Virus in Solanum nigrum L. Is Crucial for Infection

Q. Wan, Kaiyue Zheng, Jian Wu, Shan Bu, Mengting Jiao, Huijie Zhou, Yuwen Lu, Hongying Zheng, Guanwei Wu, Shaofei Rao, Hairu Chen, Fei Yan, Jiejun Peng

PMID：37515116

Epub：2023 Jun 23

Downregulation of lncRNA NEAT1 interacts with miR-374b-5p/PGAP1 axis to aggravate the development of osteoarthritis

Feiri Huang, Zhongliang Su, Jie Yang, Xizhen Zhao & Yaozeng Xu

PMID：37691099

Epub：2023 Sep 11

CD163+ and CD14+ macrophages are increased in obese children

Nikita S. Denisov,?Lyudmila V. Spirina, Iuliia G. Samoilova, Ekaterina M. Kamenskih, Ksenya A. Chubakova, Daria A. Sitnikova,Dmitry A. Svarovsky

PMID：37563845

Epub：2023 Aug 11

Modified In Vivo Matrix Gel Plug Assay for Angiogenesis Studies

Zixian Lu, Mei Yi, Taoli Chen, Yue He, Xia Fan, Hui Chen, Yinli Huang, Jianlou Niu, Xiaoqing Yan

PMID：37458432

Epub：2023 Jun 30

蛋白類

DNA polymerase POLD1 promotes proliferation and metastasis of bladder cancer by stabilizing MYC

Yejinpeng Wang, Lingao Ju, Gang Wang, Kaiyu Qian, Wan Jin, Mingxing Li, Jingtian Yu, Yiliang Shi, Yongzhi Wang, Yi Zhang, Yu Xiao & Xinghuan Wang

PMID：37105989

Epub：2023 Apr 27

Identification of an immunogenic epitope and protective antibody against the furin cleavage site of SARS-CoV-2

Lili Li, Meiling Gao, Jie Li, Xuping Xie, Hui Zhao, Yanan Wang, Xin Xu, Shulong Zu , Chunfeng Chen, Dingyi Wan, Jing Duan, Jingfeng Wang, Saba R. Aliyari, Sarah Gold, Jicai Zhang, Cheng-Feng Qin, Pei-Yong Shi, Heng Yang, Genhong Cheng

PMID：36508877

Epub：2023 Jan

Gasdermin D-mediated keratinocyte pyroptosis as a key step in psoriasis pathogenesis

Ni Lian, Yujie Chen, Sihan Chen, Ying Zhang, Hao Chen, Yong Yang, Heng Gu, Qing Chen, Min Li & Xu Chen

PMID：37673869

Epub：2023 Sep 7

UBE2S interacting with TRIM21 mediates the K11-linked ubiquitination of LPP to promote the lymphatic metastasis of bladder cancer

Kanghua Xiao, Shengmeng Peng, Junlin Lu, Ting Zhou, Xuwei Hong, Siting Chen, Guangyao Liu, Hong Li, Jian Huang, Xu Chen, Tianxin Lin

PMID：37422473

Epub：2023 Jul 8

Evaluation of the Immunological Efficacy of an LNP-mRNA Vaccine Prepared from Varicella Zoster Virus Glycoprotein gE with a Double-Mutated Carboxyl Terminus in Different Untranslated Regions in Mice

Yunfei Wang, Han Cao, Kangyang Lin, Jingping Hu, Ning Luan, Cunbao Liu

PMID：37766151

Epub：2023 Sep 11

Development of an Antigen Detection Kit Capable of Discriminating the Omicron Mutants of SARS-CoV-2

Jiaji Li,Jinrong Shi,Zhijun Zhou,Bo Yang,Jiamin Cao,Zhongsen Cao,Qiang Zeng,Zheng Hu,Xiaoming Yang

PMID：36851181

Epub：2023 Jan 30

Study of the Effects of Several SARS-CoV-2 Structural Proteins on Antiviral Immunity

Rong Yue, Fengyuan Zeng, Danjing Ma, Ziyan Meng, Xinghang Li, Zhenxiao Zhang, Haobo Zhang, Qi Li, Langxi Xu, Zhenye Niu, Dandan Li, Yun Liao, Guorun Jiang, Li Yu, Heng Zhao, Ying Zhang, Longding Liu, Qihan Li

PMID：36992107

Epub：2023 Feb 23

A single vaccination of nucleoside-modified Rabies mRNA vaccine induces prolonged highly protective immune responses in mice

Shimeng Bai, Tianhan Yang, Cuisong Zhu, Meiqi?Feng, LiZhang, Ziling Zhang, Xiang Wang, Rui Yu, Xinghao Pan, Chen Zhao, Jianqing Xu, Xiaoyan Zhang

PMID：36761167

Epub：2023 Jan 17

Pilot Study Results on Antibodies to the S- and N-Proteins of SARS-CoV-2 in Paired Sera from COVID-19 Patients with Varying Severity

Yulia Desheva, Anna Lerner, Tamara Shvedova, Olga Kopteva, Polina Kudar, Irina Koroleva, Galina Leontieva, Alexander Suvorov

PMID：36975366

Epub：2023 Feb 27

Comparison of Immune Responses between Inactivated and mRNA SARS-CoV-2 Vaccines Used for a Booster Dose in Mice

Luan N, Cao H, Wang Y, Lin K, Hu J, Liu C

PMID：37376650

Epub：2023 Jun 11

Insulin-like growth factor 1 promotes the gonadal development of Pampus argenteus by regulating energy metabolism

Yaya Li, Chang Li, Yangfei Fu, Ruixian Wang, Yang Yang, Man Zhang, Youyi Zhang, Xiangbing Wang, Guanlin Wang, Huan Jiang, Yushan Zou, Jiabao Hu, Chunyang Guo, Yajun Wang

PMID：37228017

Epub：2023 Aug 10

Molecular mimicry of the receptor-binding domain of the SARS-CoV-2 spike protein: from the interaction of spike-specific antibodies with transferrin and lactoferrin to the antiviral effects of human recombinant lactoferrin

A. V. Sokolov, I. N. Isakova-Sivak, D. A. Mezhenskaya, V. A. Kostevich, N. P. Gorbunov, A. Yu. Elizarova, V. A. Matyushenko, Yu. M. Berson, N. A. Grudinina, N. N. Kolmakov, Y. A. Zabrodskaya, A. S. Komlev, I. V. Semak, A. I. Budevich, L. G. Rudenko & V. B. Vasilyev

PMID：36334191

Epub：2023 Jun

Rationally designed multimeric nanovaccines using icosahedral DNA origami for molecularly controlled display of SARS-CoV-2 receptor binding domain

Qingqing Feng, Keman Cheng, Lizhuo Zhang, Xiaoyu Gao, Jie Liang, Guangna Liu, Nana Ma, Chen Xu, Ming Tang, Liting Chen, Xinwei Wang, Xuehui Ma, Jiajia Zou, Quanwei Shi, Pei Du, Qihui Wang, Guangjun Nie, Xiao Zhao

Epub：August 24, 2023

FUS regulates the alternative splicing of cell proliferation genes related to atherosclerosis

Jianjun Hou, Shaobing Yang, Ying Guo, Ning Yan, Shaobin Jia

PMID：37688506

Epub：2023 Sep 9

其他服務類

Comparison of the Immune Effects of an mRNA Vaccine and a Subunit Vaccine against Herpes Zoster Administered by Different Injection Methods

Kangyang Lin, Han Cao, Ning Luan, Yunfei Wang, Jingping Hu, Cunbao Liu

PMID：37243107

Epub：2023 May 20

SARS-CoV-2 RBD Conjugated to Polyglucin, Spermidine, and dsRNA Elicits a Strong Immune Response in Mice

Ekaterina A Volosnikova, Iuliia A Merkuleva, Tatiana I Esina, Dmitry N Shcherbakov, Mariya B Borgoyakova, Anastasiya A Isaeva, Valentina S Nesmeyanova, Natalia V Volkova, Svetlana V Belenkaya, Anna V Zaykovskaya, Oleg V Pyankov, Ekaterina V Starostina,?Alexey M Zadorozhny, Boris N Zaitsev, Larisa I Karpenko, Alexander A Ilyichev, Elena D Danilenko

PMID：37112720

Epub：2023 Apr 6

Metrnl Alleviates Lipid Accumulation by Modulating Mitochondrial Homeostasis in Diabetic Nephropathy

Yuxia Zhou, Lu Liu, Bangming Jin, Yixuan Wu, Lifen Xu, Xuebing Chang, Laying Hu, Guifang Wang, Yali Huang, Lingyu Song, Tian Zhang, Yuanyuan Wang, Ying Xiao, Fan Zhang, Mingjun Shi, Lingling Liu, Tuanlao Wang, Rui Yan, Bing Guo

PMID：36812572

Epub：2023 May 1

Nasal immunization with AMH-INH-RFRP DNA vaccine for improving follicle development and fertility in buffaloes

Chao Chen, Xuhong Zhao, Zhigao An, Muhammad Jamil Ahmad, Kaifeng Niu, Xinxin Zhang, Pei Nie, Jiaomei Tang, Aixin Liang, Liguo Yang

PMID：36891049

Epub：2023 Feb 20

Celastrol attenuates streptozotocin-induced diabetic cardiomyopathy in mice by inhibiting the ACE / Ang II / AGTR1 signaling pathway

Xuyong Zhao, Bingwu Huang, Jianhua Zhang, Wenjun Xiang, Ning Zhu

PMID：37700366

Epub：2023 Sep 12

Yiqi Chutan Formula Reverses Cisplatin-Induced Apoptosis and Ferroptosis of Skeletal Muscle by Alleviating Oxidative Stress

Yingchao Wu, Dajin Pi, Shuyao Zhou, Wuhong Wang, Huan Ye, Zhongjia Yi, Yiliu Chen, Mingzi Ouyang

PMID：37132527

Epub：2023 Jan-Dec

Generation of a blockage monoclonal antibody of LILRB1 against HLA-G

Yunlong Shen, Ruirui Zhang, Xiaohua Jiang, Jinliang Yang

PMID：37683901

Epub：2023 Sep 6

獎勵方案

在本公司簽訂技術服務或產品訂購合同，并在SCI期刊發(fā)表文章中或畢業(yè)論文中注明技術服務或產品由普健生物（武漢）科技有限公司

[中文：普健生物（武漢）科技有限公司；英文：

AtaGenix Laboratories Co., Ltd.(Wuhan), Wuhan, PR China

]

提供的科研工作者有權申請獎勵。 SCI期刊發(fā)表文章根據期刊影響因子獎勵客戶（每篇文章僅限1人），如下表：

發(fā)表刊物/影響因子/獎勵（二選一）

SCI期刊雜志 IF≥15.0 最高3000元普健全系產品抵扣券或最高1500元京東購物卡 SCI期刊雜志 10≤IF<15 最高3000元普健全系產品抵扣券或最高1000元京東購物卡 SCI期刊雜志 5.0≤IF<10 最高800元技術服務/產品抵扣券或最高600元京東購物卡 SCI期刊雜志 3.0≤IF<5.0 最高600元技術服務/產品抵扣券或最高200元京東購物卡

（注：影響因子以申請當年公布的最新數(shù)據為準）

在本公司簽訂技術服務或產品訂購合同，并在SCI期刊發(fā)表文章或畢業(yè)論文中注明技術服務或產品由普健生物(武漢)科技有限公司

[中文：普健生物(武漢)科技有限公司;英文：AtaGenix Laboratories Co., Ltd.(Wuhan), Wuhan, PR China]

提供的科研工作者有權申請獎勵。

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關于我們?

普健生物（AtaGenix）于2012年在武漢成立，作為武漢國家生物產業(yè)基地公共服務平臺——光谷抗體發(fā)現(xiàn)與篩選公共服務平臺，普健生物（AtaGenix）專注于重組蛋白、抗體、診斷原料、抗體藥物發(fā)現(xiàn)等自主技術平臺的建設和下游生物醫(yī)藥產品的戰(zhàn)略合作。經過10年的發(fā)展，普健生物已成為一家立足武漢，業(yè)務覆蓋全國、輻射全球的高新技術服務企業(yè)。目前公司擁有4700平米自建實驗室（包含800平高標準BSL-2級細胞房），擁有齊全蛋白抗體開發(fā)設備500余套，包括高通量蛋白純化儀、Agilent 流式細胞分析儀，全自動HPLC分析儀，openSPR蛋白、抗體親和力測定儀，Olympus熒光顯微鏡， BTX電融合儀，2*7L微生物發(fā)酵罐，中試型高壓均質機，全自動管式化學發(fā)光儀，以及配套的高速離心機，細胞計數(shù)儀及大容量細胞培養(yǎng)搖床。公司先后獲得榮譽：

3551人才計劃、高新技術企業(yè)、技術先進型服務企業(yè)、光谷瞪羚企業(yè)

。