iRGD腫瘤穿透肽修飾的溶瘤腺病毒顯示增強(qiáng)的腫瘤傳導(dǎo)，腫瘤內(nèi)傳播和抗腫瘤功效基因療法。

編號:128437

中文名稱:iRGD peptide

英文名:c(CRGDKGPDC)

CAS號:1392278-76-0

單字母:H2N-CRGDKGPDC-OH(Disulfide Bridge:C1-C9)

三字母:H2N-Cys-Arg-Gly-Asp-Lys-Gly-Pro-Asp-Cys-COOH(Disulfide Bridge:Cys1-Cys9)

氨基酸個數(shù):9

分子式:C35H57N13O14S2

平均分子量:948.04

精確分子量:947.36

等電點(diǎn)(PI):8.83

pH=7.0時的凈電荷數(shù):1.91

平均親水性:1.6666666666667

疏水性值:-1.42

標(biāo)簽:<span class="nolink">二硫鍵環(huán)肽<span class="nolink">RGD、RAD肽<span class="nolink">細(xì)胞穿膜肽

10.1038/gt.2014.52iRGD tumor-penetrating peptide-modified oncolytic adenovirus shows enhanced tumor transduction, intratumoral dissemination and antitumor efficacy

10.1016/j.biopha.2017.06.103Combination of NRP1-mediated iRGD with 5-fluorouracil suppresses proliferation, migration and invasion of gastric cancer cells