艾美捷LKT Labs 胰高血糖素樣肽II,大鼠解決方案
胰高血糖素樣肽2(GLP-2)是一種主要在腸道和胰腺中合成的肽激素。GLP-2結(jié)合并激活GLP-2受體,表現(xiàn)出血管擴(kuò)張,抗高血壓,抗抑郁和胃腸動(dòng)力調(diào)節(jié)活性。在動(dòng)物模型中,GLP-2增加腸道血流量并降低平均動(dòng)脈血壓。GLP-2通過(guò)涉及PKA激活的機(jī)制增強(qiáng)L型電壓門控Ca2+通道。此外,GLP-2減少了接受強(qiáng)制游泳測(cè)試的動(dòng)物的靜止時(shí)間。這種肽刺激細(xì)胞增殖,抑制化療誘導(dǎo)的腸道粘膜萎縮。GLP-2還可以減少胃排空和胃腸蠕動(dòng)。

艾美捷LKT?Labs?胰高血糖素樣肽II,大鼠?#G4485參數(shù)說(shuō)明:?
Cas No.:89750-15-2
純度:≥95%
公式:C165H254N44O55S
配方重量:3766.2
同義詞:GLP-2
儲(chǔ)存溫度:-20°C
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LKT?Labs?胰高血糖素樣肽II,大鼠文獻(xiàn)引用:
Sasaki-Hamada S, Ito K, Oka JI. Neuronal Fos-like immunoreactivity associated with dexamethasone-induced hypertension in rats and effects of glucagon-like peptide-2. Life Sci. 2013 Oct 24. pii: S0024-3205(13)00618-8. [Epub ahead of print]. PMID: 24513200.
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Hansen LB. GLP-2 and mesenteric blood flow. Dan Med J. 2013 May;60(5):B4634. PMID: 23673268.
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Rasmussen AR, Viby NE, Hare KJ, et al. The intestinotrophic peptide, GLP-2, counteracts the gastrointestinal atrophy in mice induced by the epidermal growth factor receptor inhibitor, erlotinib, and cisplatin. Dig Dis Sci. 2010 Oct;55(10):2785-96. PMID: 20112065.
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Wang Y, Guan X. GLP-2 potentiates L-type Ca2+ channel activity associated with stimulated glucose uptake in hippocampal neurons. Am J Physiol Endocrinol Metab. 2010 Feb;298(2):E156-66. PMID: 19920220.
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Iwai T, Hayashi Y, Narita S, et al. Antidepressant-like effects of glucagon-like peptide-2 in mice occur via monoamine pathways. Behav Brain Res. 2009 Dec 1;204(1):235-40. PMID: 19539656.
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Mojsov S, Kopczynski MG, Habener JF. Both amidated and nonamidated forms of glucagon-like peptide I are synthesized in the rat intestine and the pancreas. J Biol Chem. 1990 May 15;265(14):8001-8. PMID: 1692320.
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