達(dá)夫奈肽/Davunetide/CAS211439-12-2 是一種鼻內(nèi)神經(jīng)肽療法，來(lái)源于活動(dòng)依賴性神經(jīng)保護(hù)蛋白 (ADNP)，ADNP 是神經(jīng)膠質(zhì)細(xì)胞在暴露于血管活性腸肽時(shí)釋放的一種生長(zhǎng)因子。其中包含八個(gè)氨基酸 Asn-Ala-Pro-Val-Ser-Ile-Pro-Gln 的肽。該肽具有高效的神經(jīng)保護(hù)活性。

Name: 達(dá)夫奈肽/Davunetide
Synonyms: NAP, AL-108
Chemical Name: NAPVSIPQ

達(dá)夫奈肽/Davunetide (AL-108, NAP) is an eightamino acid peptide that promotes microtubule stability and decreases tau phosphorylation in pre-clinical studies. Since PSP is tightly linked to tau pathology, davunetide could be an effective treatment for Progressive supranuclear palsy (PSP). The goals of this study were to evaluate the efficacy and safety of davunetide in PSP.