艾美捷人因子Ⅻ參數(shù)說明和文獻(xiàn)參考
因子XII（LOCARNO）是一種由基因序列異常引起的疾病。診斷和治療需要采用分子診斷技術(shù)。艾美捷可提供致力找到病因、阻斷遺傳的基因解碼和出于風(fēng)險(xiǎn)考慮的基因檢測。
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XIIa的抑制劑包括?C1-INH、α2-抗纖溶酶、α2-巨球蛋白和抗凝血酶?III。在生理濃度下，這些抑制劑的相對有效性分別為?91 : 4.5 : 3 : 1.5。?C1-INH與XII的比例與因子VII的“冷激活”和血漿儲(chǔ)存過程中腎素原向腎素的轉(zhuǎn)化有關(guān)。人因子?XII是通過免疫親和層析從新鮮冷凍血漿中制備的，并以50%（體積/體積）甘油/水的形式提供，可在-20℃下儲(chǔ)存。
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艾美捷人因子Ⅻ?HCXII-0155相關(guān)參數(shù)：
Localization:?等離子
血漿濃度：40μg/ml（3）
作用方式：Zymogen；絲氨酸蛋白酶因子XIIa的前體；
激肽釋放酶/HMWK/陰離子表面復(fù)合物激活
闡明內(nèi)在途徑
分子量：80000（2）
消光系數(shù)：E1 cm，280 nm=14.0
等電點(diǎn)：6.8
結(jié)構(gòu)：單鏈（Mr=80000），基于6個(gè)域組織
關(guān)于序列同源性（5）
碳水化合物百分比：17%
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Localization: Plasma
Plasma concentration: 40 μg/ml (3)
Mode of action: Zymogen; precursor to the serine protease factor XIIa;
activated by kallikrein/HMWK/anionic surface complex to
intitiate the intrinsic pathway
Molecular weight: 80,000 (2)
Extinction coefficient: E1 cm, 280 nm = 14.0
Isoelectric point: 6.8
Structure: single chain (Mr = 80,000), organized into 6 domains based
on sequence homology (5)
Percent carbohydrate: 17%
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人因子Ⅻ?HCXII-0155文獻(xiàn)參考：
1. Schmaier, A.H., et al., in Hemostasis and Thrombosis, ed. R.W. Colman, J. Hirsh, V.J. Marder and
E.W. Salzman, pp 18-38, J.B. Lippincott Company, Philadelphia, 1987.
2. Griffin, J.H. and Cochrane, C.G., Methods Enzymol., 45, 56-65 (1976).
3. Saito, H., et al., J Lab Clin., 88, 506 (1976).
4. McMullen, B.A. and Fujikawa, N., J. Biol. Chem., 260, 5328 (1985).
5. Davie, E.W., in Hemostasis and Thrombosis, ed. R.W. Colman, J. Hirsh, V.J. Marder and E.W.
Salzman, pp 242-267, J.B. Lippincott Company, Philadelphia, 1987.
6. Griffin, J.H., Proc. Natl. Acad. Sci. USA, 75, 1998 (1978).
7. McMillin, L.R., et al., J. Clin. Invest., 54, 1312 (1974).
8. Revak, S.D., et al., J. Clin. Invest., 59, 1167 (1977).
9. Fujikawa, K., et al., Biochemistry, 16, 4182 (1977).
10. Bonno, N., et al., in New Comprehensive Biochemistry, ed. R.F.A. Zwaal and H.C.Hemker,
pp. 103-128, Elsevier, Amsterdam, 1986.
11. Claeys, H. and Collen, D. (1978) Eur. J. Biochem., 87, 69 (1978).
12. Revak, S.D. and Cochrane, C.G., J. Clin. Invest., 57, 852 (1976).
13. Cochrane, C.G., et al., J. Exp. Med., 138, 1564 (1973).
14. Revak, S.D., et al., J. Exp. Med., 147, 719 (1978).
15. Ghebrehiwet, B., et al., J. Clin. Invest., 71, 1458 (1983).
16. DeAgostini, A., et al., J. Clin. Invest., 73, 1542 (1984).
17. Rathoff, O.D., et al., J. Exp. Med., 129, 315 (1969).
18. Stead, N., et al., J. Biol Chem., 251, 6481 (1976).
19. Pixley, R.A., et al., J. Biol Chem., 260, 1723 (1985).
20. Gjonnass, H., Thromb. Diath. Haemorrh., 28, 182 (1972).
21. Radcliffe, R., et al., Blood, 59, 611 (1977).
