英文名：BK-1361，cyclo(RLsKDK)

CAS：1975145-82-4

供應(yīng)商：西安凱新生物科技有限公司

化學(xué)式：C31H57N11O9

分子量：727.865

密度： 1.46±0.1 g/cm3(Predicted)

酸度系數(shù)(pKa)：4.01±0.10(Predicted)

結(jié)構(gòu)式：

反應(yīng)機(jī)理：

BK-1361（BK1361，cyclo-RLsKDK）是一種具有RLsKDK（s=D-絲氨酸）的環(huán)肽，其作為ADAM8的有效選擇性抑制劑起作用，IC50為120nM，對(duì)ADAM 9,10,12沒有顯示出顯著活性。在基于細(xì)胞的脫落測定中抑制CD23的脫落，IC50為182nM。?

BK-1361(BK1361, cyclo-RLsKDK) is a cyclic peptide with RLsKDK (s=D-serine) that functions as a potent, selective inhibitor of ADAM8 with IC50 of 120 nM; displays no significant activity against ADAM 9, 10, 12, 17 , as well as MMP-2, -9, and -14 at 10 uM; inhibit shedding of CD23 with IC50 of 182 nM in cell-based shedding assays, reduces migration/invasion of pancreatic cancer cells and less ERK1/2 and MMP activation, causes change in cell morphology; decreases tumour burden and metastasis of implanted pancreatic tumour cells and provides improved metrics of clinical symptoms and survival in Kras(G12D)-driven mouse model of PDAC.

產(chǎn)品形式：

1.外觀為固體/粉末

2.溶于大部分有機(jī)溶劑，溶于水

3.純度標(biāo)準(zhǔn)95+，詳情可在線咨詢

保存建議：避免反復(fù)凍融，避光避濕保存，儲(chǔ)液應(yīng)該立即使用，-20℃以下冰凍。從冰箱取出產(chǎn)品后,置于室溫回溫至少30min-1h，再開蓋，以避免受潮。

同類型試劑：

Cyclo-(D-Tyr-Gly)

Cyclo(-Tyr-Hpro)

cyclo(His-Pro)

cyclo(Val-Val)

Cyclo(-Leu-Pro)

Cyclo(Leu-Tyr)

Cyclo(D-Leu-L-Pro)

Cyclo(D-Phe-L-Pro)

(3-Azidobutyl)cyclohexane

(Azidomethyl)-cyclohexane

1,7-Dioxa-4,10-diazacyclododecane

Cyclo(L-Phe-trans-4-hydroxy-L-Pro)

Cyclo(L-Leu-trans-4-hydroxy-L-Pro)

1,1,3,3,5,5-HexamethylCyclotrisilazane

1,1,3,3,5,5,7,7-OctamethylCyclotetrasilazane

cyclo(Arg-Gly-Asp-D-Tyr-Val)

Cyclo(-Arg-Ala-Asp-D-Phe-Lys)

cyclo(Arg-Gly-Asp-D-Phe-Cys)

Cyclo(-Arg-Gly-Asp-D-Tyr-Lys)

Cyclo(-Gly-Arg-Gly-Asp-Ser-Pro)

Cyclo(-Arg-Ala-Asp-D-Tyr-Lys)

cyclo(Arg-Gly-Asp-d-Phe-Glu)

注意點(diǎn)：僅用于科學(xué)研究或者工業(yè)應(yīng)用等非醫(yī)療目的，不可用于人類，非藥用，非食用

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