聲明：本專(zhuān)欄主要對(duì)生命科學(xué)領(lǐng)域的一些期刊文章標(biāo)題進(jìn)行翻譯，所有內(nèi)容均由本人手工整理翻譯。由于本人專(zhuān)業(yè)為生物分析相關(guān)，其他領(lǐng)域如果出現(xiàn)翻譯錯(cuò)誤請(qǐng)諒解。

1.Parabrachial-to-parasubthalamic nucleus pathway mediates fear-induced suppression of feeding in male mice.

副乳頭至副丘腦通路介導(dǎo)雄性小鼠恐懼誘導(dǎo)的攝食抑制。

2.TAPE-seq is a cell-based method for predicting genome-wide off-target effects of prime editor.

TAPE-seq是一種基于細(xì)胞的方法，用于預(yù)測(cè)素編輯的全基因組脫靶效應(yīng)。

3.Efficient neural codes naturally emerge through gradient descent learning.

高效的神經(jīng)代碼通過(guò)梯度下降學(xué)習(xí)自然出現(xiàn)。

4.Metagenomic analysis reveals unexplored diversity of archaeal virome in the human gut.

元基因組學(xué)分析揭示了人類(lèi)腸道中未被開(kāi)發(fā)的古細(xì)菌病毒群的多樣性。

5.Genomics and phenomics of body mass index reveals a complex disease network.

體重指數(shù)的基因組學(xué)和表型組學(xué)揭示了一個(gè)復(fù)雜的疾病網(wǎng)絡(luò)。

6.Dynamic 18F-Pretomanid PET imaging in animal models of TB meningitis and human studies.

動(dòng)態(tài)18F-Pretomanid PET成像在結(jié)核性腦膜炎動(dòng)物模型和人類(lèi)研究中的應(yīng)用。

7.Multistep diversification in spatiotemporal bacterial-phage coevolution.

時(shí)空細(xì)菌-噬菌體協(xié)同進(jìn)化中的多步驟多樣化。

8.High-frequency synthetic apomixis in hybrid rice.

雜交水稻中的高頻合成apomixis。

9.Ligand recognition and activation of neuromedin U receptor 2.

神經(jīng)梅素U受體2的配體識(shí)別和激活.

10.Broadly neutralizing and protective nanobodies against SARS-CoV-2 Omicron subvariants BA.1, BA.2, and BA.4/5 and diverse sarbecoviruses.

針對(duì)SARS-CoV-2 Omicron亞型BA.1、BA.2和BA.4/5以及多種沙貝科病毒的廣泛中和和保護(hù)性納米抗體。

11.Prediction of designer-recombinases for DNA editing with generative deep learning.

用生成式深度學(xué)習(xí)預(yù)測(cè)用于DNA編輯的設(shè)計(jì)者-重組酶。

12.The lipid flippase SLC47A1 blocks metabolic vulnerability to ferroptosis.

脂質(zhì)翻轉(zhuǎn)酶SLC47A1阻斷了新陳代謝對(duì)鐵銹病的脆弱性。

13.Genome-wide identification of genes required for alternative peptidoglycan cross-linking in Escherichia coli revealed unexpected impacts of β-lactams.

大腸桿菌中替代性肽聚糖交聯(lián)所需基因的全基因組鑒定揭示了β-內(nèi)酰胺的意外影響。

14.Single-cell transcriptomic analysis identifies murine heart molecular features at embryonic and neonatal stages.

單細(xì)胞轉(zhuǎn)錄組分析確定了胚胎和新生兒階段的小鼠心臟分子特征。

15.PRSS2 remodels the tumor microenvironment via repression of Tsp1 to stimulate tumor growth and progression.

PRSS2通過(guò)抑制Tsp1重塑腫瘤微環(huán)境，刺激腫瘤的生長(zhǎng)和發(fā)展。

16.Transcriptional reprogramming from innate immune functions to a pro-thrombotic signature by monocytes in COVID-19.

COVID-19中的單核細(xì)胞從先天免疫功能到親血栓特征的轉(zhuǎn)錄重編程。

17.Implantable niche with local immunosuppression for islet allotransplantation achieves type 1 diabetes reversal in rats.

植入式壁龕與局部免疫抑制的胰島異位移植實(shí)現(xiàn)了大鼠1型糖尿病的逆轉(zhuǎn)。

18.Arabidopsis γ-H2A.X-INTERACTING PROTEIN participates in DNA damage response and safeguards chromatin stability.

擬南芥γ-H2A.X-反應(yīng)蛋白參與DNA損傷反應(yīng)，保障染色質(zhì)穩(wěn)定。

19.Multimodal monitoring of human cortical organoids implanted in mice reveal functional connection with visual cortex.

植入小鼠體內(nèi)的人類(lèi)皮層器官的多模態(tài)監(jiān)測(cè)揭示了與視覺(jué)皮層的功能聯(lián)系。

20.Altered sulfation status of FAM20C-dependent chondroitin sulfate is associated with osteosclerotic bone dysplasia.

FAM20C依賴(lài)的硫酸軟骨素的硫酸化狀態(tài)改變與骨硬化性骨發(fā)育不良有關(guān)。

21.Diverse monogenic subforms of human spermatogenic failure.

人類(lèi)精子生成障礙的多種單基因亞型。

22.Pharmacological inhibition of Lin28 promotes ketogenesis and restores lipid homeostasis in models of non-alcoholic fatty liver disease.

藥物抑制Lin28促進(jìn)非酒精性脂肪肝模型的生酮作用并恢復(fù)脂質(zhì)平衡。

23.A pH-responsive T1-T2 dual-modal MRI contrast agent for cancer imaging.

一種用于癌癥成像的pH反應(yīng)性T1-T2雙模式MRI造影劑。

24.A genome-wide CRISPR screen identifies WDFY3 as a regulator of macrophage efferocytosis.

全基因組CRISPR篩查發(fā)現(xiàn)WDFY3是巨噬細(xì)胞滲出的調(diào)節(jié)器。

25.Peptidoglycan recycling mediated by an ABC transporter in the plant pathogen Agrobacterium tumefaciens.

植物病原體腫瘤農(nóng)桿菌中由ABC轉(zhuǎn)運(yùn)體介導(dǎo)的肽聚糖循環(huán)。

26.Regulatory basis for reproductive flexibility in a meningitis-causing fungal pathogen.

致使腦膜炎的真菌病原體繁殖靈活性的調(diào)節(jié)基礎(chǔ)。

27.Simultaneous profiling of histone modifications and DNA methylation via nanopore sequencing.

通過(guò)納米孔測(cè)序?qū)M蛋白修飾和DNA甲基化進(jìn)行同步分析。

28.Engineering inducible biomolecular assemblies for genome imaging and manipulation in living cells.

用于活細(xì)胞中基因組成像和操作的可誘導(dǎo)生物分子組合工程。

29.Continuous cholinergic-dopaminergic updating in the nucleus accumbens underlies approaches to reward-predicting cues.

阿肯色核中持續(xù)的膽堿能-多巴胺能更新是獎(jiǎng)勵(lì)預(yù)測(cè)線索的基礎(chǔ)。

30.An astrocytic signaling loop for frequency-dependent control of dendritic integration and spatial learning.

樹(shù)突整合和空間學(xué)習(xí)的頻率依賴(lài)性控制的星形細(xì)胞信號(hào)回路。

31.Topographic organization of eye-position dependent gain fields in human visual cortex.

人類(lèi)視覺(jué)皮層中與眼位有關(guān)的增益場(chǎng)的地形組織。

32.Force-tuned avidity of spike variant-ACE2 interactions viewed on the single-molecule level.

在單分子水平上觀察穗狀變體-ACE2相互作用的力調(diào)控?zé)岫取?/p>

33.Deconstructing body axis morphogenesis in zebrafish embryos using robot-assisted tissue micromanipulation.

使用機(jī)器人輔助組織微操作解構(gòu)斑馬魚(yú)胚胎的體軸形態(tài)發(fā)生。

34.A randomized trial of oral gamma aminobutyric acid (GABA) or the combination of GABA with glutamic acid decarboxylase (GAD) on pancreatic islet endocrine function in children with newly diagnosed type 1 diabetes.

口服γ-氨基丁酸（GABA）或GABA與谷氨酸脫羧酶（GAD）組合對(duì)新診斷的1型糖尿病兒童的胰島內(nèi)分泌功能的隨機(jī)試驗(yàn)。

35.Thousands of human non-AUG extended proteoforms lack evidence of evolutionary selection among mammals.

數(shù)以千計(jì)的人類(lèi)非AUG擴(kuò)展蛋白形式在哺乳動(dòng)物中缺乏進(jìn)化選擇的證據(jù)。

36.Evolutionary rescue of resistant mutants is governed by a balance between radial expansion and selection in compact populations.

抗性突變體的進(jìn)化救援受緊湊種群中的徑向擴(kuò)張和選擇之間的平衡所支配。

37.Targeting anti-apoptotic pathways eliminates senescent melanocytes and leads to nevi regression.

靶向抗凋亡途徑可消除衰老的黑色素細(xì)胞并導(dǎo)致痣的消退。

38.Control of SARS-CoV-2 infection by MT1-MMP-mediated shedding of ACE2.

通過(guò)MT1-MMP介導(dǎo)的ACE2的脫落控制SARS-CoV-2的感染。

39.Glucose absorption drives cystogenesis in a human organoid-on-chip model of polycystic kidney disease.

葡萄糖的吸收推動(dòng)了多囊腎的人類(lèi)類(lèi)器官芯片模型中的囊腫生成。

40.Exon junction complex shapes the m6A epitranscriptome.

外顯子連接復(fù)合體塑造了m6A外顯子組。

41.Paratype: a genotyping tool for Salmonella Paratyphi A reveals its global genomic diversity.

Paratype：一種副傷寒沙門(mén)氏菌A的基因分型工具，揭示了其全球基因組的多樣性。

42.Effects of phytoplankton, viral communities, and warming on free-living and particle-associated marine prokaryotic community structure.

浮游植物、病毒群落和氣候變暖對(duì)自由生活的和與顆粒相關(guān)的海洋原核生物群落結(jié)構(gòu)的影響。

43.Reply to: A balanced measure shows superior performance of pseudobulk methods in single-cell RNA-sequencing analysis.

回應(yīng)：?一個(gè)平衡的措施顯示了單細(xì)胞RNA測(cè)序分析中假包絡(luò)方法的優(yōu)越性能。

44.A balanced measure shows superior performance of pseudobulk methods in single-cell RNA-sequencing analysis.

一個(gè)平衡的措施顯示了假包絡(luò)方法在單細(xì)胞RNA測(cè)序分析中的優(yōu)越性能。

45.Benchmarking tools for detecting longitudinal differential expression in proteomics data allows establishing a robust reproducibility optimization regression approach.

檢測(cè)蛋白質(zhì)組學(xué)數(shù)據(jù)中縱向差異表達(dá)的基準(zhǔn)工具可以建立一個(gè)強(qiáng)大的可重復(fù)性?xún)?yōu)化回歸方法。

46.A conformation-specific nanobody targeting the nicotinamide mononucleotide-activated state of SARM1.

一種針對(duì)SARM1的煙酰胺單核苷酸激活狀態(tài)的構(gòu)象特異性納米抗體。

47.Graph-based pangenomics maximizes genotyping density and reveals structural impacts on fungal resistance in melon.

基于圖形的泛基因組學(xué)最大限度地提高了基因分型密度，并揭示了結(jié)構(gòu)對(duì)瓜類(lèi)真菌抗性的影響。

48.Cross-kingdom synthetic microbiota supports tomato suppression of Fusarium wilt disease.

跨領(lǐng)域的合成微生物群支持番茄抑制鐮刀菌枯萎病。

49.Memory for nonadjacent dependencies in the first year of life and its relation to sleep.

出生后第一年的非相依性記憶及其與睡眠的關(guān)系。

50.Divergent roles of herbivory in eutrophying forests.

食草動(dòng)物在富營(yíng)養(yǎng)化森林中的不同作用。

51.A method to build extended sequence context models of point mutations and indels.

一種建立點(diǎn)突變和縮進(jìn)點(diǎn)的擴(kuò)展序列環(huán)境模型的方法。

52.Actin-microtubule cytoskeletal interplay mediated by MRTF-A/SRF signaling promotes dilated cardiomyopathy caused by LMNA mutations.

MRTF-A/SRF信號(hào)介導(dǎo)的肌動(dòng)蛋白-微管細(xì)胞骨架相互作用促進(jìn)LMNA突變引起的擴(kuò)張型心肌病。

53.Design of a self-driven probiotic-CRISPR/Cas9 nanosystem for sono-immunometabolic cancer therapy.

設(shè)計(jì)一個(gè)自我驅(qū)動(dòng)的益生菌-CRISPR/Cas9納米系統(tǒng)，用于聲免疫代謝癌癥治療。

54.Astrocytes amplify neurovascular coupling to sustained activation of neocortex in awake mice.

星形膠質(zhì)細(xì)胞放大了神經(jīng)血管耦合對(duì)清醒小鼠新皮質(zhì)的持續(xù)激活作用。

55.Synaptic basis of a sub-second representation of time in a neural circuit model.

神經(jīng)回路模型中時(shí)間的亞秒表征的突觸基礎(chǔ)。

56.Safeguarding genome integrity during gene-editing therapy in a mouse model of age-related macular degeneration.

在老年性黃斑變性小鼠模型的基因編輯治療中保障基因組的完整性。

57.Median raphe serotonergic neurons projecting to the interpeduncular nucleus control preference and aversion.

投射到肌肉間核的中脊5-羥色胺能神經(jīng)元控制著偏好和厭惡。

58.Epigenome-wide meta-analysis identifies DNA methylation biomarkers associated with diabetic kidney disease.

表觀基因組范圍內(nèi)的薈萃分析確定了與糖尿病腎病相關(guān)的DNA甲基化生物標(biāo)志物。

59.Modulating glycosphingolipid metabolism and autophagy improves outcomes in pre-clinical models of myeloma bone disease.

調(diào)控糖脂代謝和自噬可改善骨髓瘤骨病臨床前模型的結(jié)果。

60.Loss of SUMO-specific protease 2 causes isolated glucocorticoid deficiency by blocking adrenal cortex zonal transdifferentiation in mice.

SUMO特異性蛋白酶2的缺失通過(guò)阻斷小鼠腎上腺皮質(zhì)帶狀轉(zhuǎn)分化而導(dǎo)致孤立的糖皮質(zhì)激素缺乏癥。

61.Biomolecular condensate phase diagrams with a combinatorial microdroplet platform.

用組合式微滴平臺(tái)的生物分子凝結(jié)物相圖。

62.Tiltable objective microscope visualizes selectivity for head motion direction and dynamics in zebrafish vestibular system.

可傾斜物鏡觀察斑馬魚(yú)前庭系統(tǒng)中頭部運(yùn)動(dòng)方向和動(dòng)態(tài)的選擇性。

63.Calcium-permeable channelrhodopsins for the photocontrol of calcium signalling.

鈣通透性通道荷爾蒙蛋白對(duì)鈣信號(hào)的光控作用。

64.The UFM1 system regulates ER-phagy through the ufmylation of CYB5R3.

UFM1系統(tǒng)通過(guò)CYB5R3的ufmylation調(diào)控ER-phagy。

65.Protein complex prediction using Rosetta, AlphaFold, and mass spectrometry covalent labeling.

使用Rosetta、AlphaFold和質(zhì)譜共價(jià)標(biāo)簽進(jìn)行蛋白質(zhì)復(fù)合物預(yù)測(cè)。

66.Proteome-wide 3D structure prediction provides insights into the ancestral metabolism of ancient archaea and bacteria.

整個(gè)蛋白質(zhì)組的三維結(jié)構(gòu)預(yù)測(cè)提供了對(duì)古代古細(xì)菌和細(xì)菌的祖先代謝的見(jiàn)解。

67.SOX17-positive rete testis epithelium is required for Sertoli valve formation and normal spermiogenesis in the male mouse.

雄性小鼠Sertoli瓣的形成和正常精子生成需要SOX17陽(yáng)性的睪丸上皮細(xì)胞。

68.Sourcing thermotolerant poly(ethylene terephthalate) hydrolase scaffolds from natural diversity.

從自然多樣性中尋找耐高溫的聚對(duì)苯二甲酸乙二醇酯水解酶支架。

69.Huntington disease oligodendrocyte maturation deficits revealed by single-nucleus RNAseq are rescued by thiamine-biotin supplementation.

通過(guò)單核RNAseq揭示的亨廷頓病少突膠質(zhì)細(xì)胞成熟缺陷可通過(guò)補(bǔ)充硫胺素-生物素得到拯救。

70.Antibodies targeting the neuraminidase active site inhibit influenza H3N2 viruses with an S245N glycosylation site.

靶向神經(jīng)氨酸酶活性位點(diǎn)的抗體可抑制具有S245N糖基化位點(diǎn)的H3N2流感病毒。

71.Structure of a RecT/Redβ family recombinase in complex with a duplex intermediate of DNA annealing.

RecT/Redβ家族重組酶與DNA退火的雙倍體中間物復(fù)合的結(jié)構(gòu)。

72.Molecular mechanism of antibody neutralization of coxsackievirus A16.

柯薩奇病毒A16的抗體中和的分子機(jī)制。

73.Machine learning assisted interferometric structured illumination microscopy for dynamic biological imaging.

機(jī)器學(xué)習(xí)輔助的干涉結(jié)構(gòu)照明顯微鏡用于動(dòng)態(tài)生物成像。

74.Morphological control enables nanometer-scale dissection of cell-cell signaling complexes.

形態(tài)學(xué)控制使細(xì)胞-細(xì)胞信號(hào)復(fù)合體的納米級(jí)剖析成為可能。

75.Exceptional preservation and foot structure reveal ecological transitions and lifestyles of early theropod flyers.

特殊的保存和足部結(jié)構(gòu)揭示了早期恒溫動(dòng)物的生態(tài)過(guò)渡和生活方式。

76.Combining genome-wide association studies highlight novel loci involved in human facial variation.

結(jié)合全基因組關(guān)聯(lián)研究突出了參與人類(lèi)面部變異的新位點(diǎn)。

77.Dynamic partitioning of branched-chain amino acids-derived nitrogen supports renal cancer progression.

支鏈氨基酸衍生的氮的動(dòng)態(tài)分配支持腎癌的發(fā)展。

78.STREAMING-tag system reveals spatiotemporal relationships between transcriptional regulatory factors and transcriptional activity.

STREAMING-標(biāo)簽系統(tǒng)揭示了轉(zhuǎn)錄調(diào)控因子和轉(zhuǎn)錄活動(dòng)之間的時(shí)空關(guān)系。

79.Hippocampus as a sorter and reverberatory integrator of sensory inputs.

海馬是感覺(jué)輸入的分揀器和混響集成器。

80.Mechanism of human Lig1 regulation by PCNA in Okazaki fragment sealing.

岡崎片段密封中PCNA對(duì)人類(lèi)Lig1的調(diào)節(jié)機(jī)制。

81.Synthesis of macrocyclic nucleoside antibacterials and their interactions with MraY.

大環(huán)核苷類(lèi)抗菌劑的合成及其與MraY的相互作用。

82.Chronic exposure to synthetic food colorant Allura Red AC promotes susceptibility to experimental colitis via intestinal serotonin in mice.

慢性接觸合成食品著色劑Allura Red AC通過(guò)小鼠腸道5-羥色胺促進(jìn)對(duì)實(shí)驗(yàn)性結(jié)腸炎的敏感性。

83.Wood structure explained by complex spatial source-sink interactions.

用復(fù)雜的空間源-匯相互作用解釋木材結(jié)構(gòu)。

84.Hedgehog-mediated gut-taste neuron axis controls sweet perception in Drosophila.

刺猬介導(dǎo)的腸道-味覺(jué)神經(jīng)元軸控制果蠅的甜味感知。

85.A comparison of the genes and genesets identified by GWAS and EWAS of fifteen complex traits.

15個(gè)復(fù)雜性狀的GWAS和EWAS確定的基因和基因組的比較。

86.Bioenergetics of pollen tube growth in Arabidopsis thaliana revealed by ratiometric genetically encoded biosensors.

擬南芥花粉管生長(zhǎng)的生物能量學(xué)由比率基因編碼的生物傳感器揭示。

87.Endothelial cells regulate astrocyte to neural progenitor cell trans-differentiation in a mouse model of stroke.

內(nèi)皮細(xì)胞調(diào)節(jié)中風(fēng)小鼠模型中星形細(xì)胞向神經(jīng)祖細(xì)胞的轉(zhuǎn)分化。

88.Rational enzyme design for enabling biocatalytic Baldwin cyclization and asymmetric synthesis of chiral heterocycles.

合理設(shè)計(jì)酶以實(shí)現(xiàn)生物催化的Baldwin環(huán)化和手性雜環(huán)的不對(duì)稱(chēng)合成。

89.Rapid and reversible optogenetic silencing of synaptic transmission by clustering of synaptic vesicles.

通過(guò)突觸小泡的聚集對(duì)突觸傳遞進(jìn)行快速和可逆的光遺傳學(xué)沉默。

90.Climate warming has compounded plant responses to habitat conversion in northern Europe.

氣候變暖加劇了歐洲北部植物對(duì)棲息地轉(zhuǎn)換的反應(yīng)。

91.Number of simultaneously acting global change factors affects composition, diversity and productivity of grassland plant communities.

同時(shí)作用的全球變化因素的數(shù)量影響草原植物群落的組成、多樣性和生產(chǎn)力。

92.Targeting the transcription factor HES1 by L-menthol restores protein phosphatase 6 in keratinocytes in models of psoriasis.

L-薄荷醇靶向轉(zhuǎn)錄因子HES1可恢復(fù)銀屑病模型中角質(zhì)層細(xì)胞的蛋白磷酸酶6。

93.USP5-Beclin 1 axis overrides p53-dependent senescence and drives Kras-induced tumorigenicity.

USP5-Beclin 1軸推翻了p53依賴(lài)性的衰老并驅(qū)動(dòng)Kras誘導(dǎo)的致瘤性。

94.Translation factor eIF5a is essential for IFNγ production and cell cycle regulation in primary CD8+ T lymphocytes.

翻譯因子eIF5a對(duì)初級(jí)CD8+T淋巴細(xì)胞的IFNγ產(chǎn)生和細(xì)胞周期調(diào)節(jié)至關(guān)重要。

95.Serum metabolic traits reveal therapeutic toxicities and responses of neoadjuvant chemoradiotherapy in patients with rectal cancer.

血清代謝特征揭示了直腸癌患者新輔助化放療的治療毒性和反應(yīng)。

96.Biodiversity stabilizes plant communities through statistical-averaging effects rather than compensatory dynamics.

生物多樣性通過(guò)統(tǒng)計(jì)平均效應(yīng)而不是補(bǔ)償性動(dòng)態(tài)穩(wěn)定植物群落。

97.Closed-loop direct control of seizure focus in a rodent model of temporal lobe epilepsy via localized electric fields applied sequentially.

通過(guò)連續(xù)施加的局部電場(chǎng)在嚙齒動(dòng)物的顳葉癲癇模型中對(duì)癲癇病灶進(jìn)行閉環(huán)直接控制。

98.Extensive substrate recognition by the streptococcal antibody-degrading enzymes IdeS and EndoS.

鏈球菌抗體降解酶IdeS和EndoS的廣泛底物識(shí)別。

99.Muscle 4EBP1 activation modifies the structure and function of the neuromuscular junction in mice.

肌肉4EBP1的激活修改了小鼠神經(jīng)肌肉接頭的結(jié)構(gòu)和功能。

100.Chemical reaction-mediated covalent localization of bacteria.

化學(xué)反應(yīng)介導(dǎo)的細(xì)菌共價(jià)定位。

101.A secreted effector with a dual role as a toxin and as a transcriptional factor.

一種具有毒素和轉(zhuǎn)錄因子雙重作用的分泌型效應(yīng)物。

102.Dysfunctional Sars-CoV-2-M protein-specific cytotoxic T lymphocytes in patients recovering from severe COVID-19.

重癥COVID-19恢復(fù)期患者的Sars-CoV-2-M蛋白特異性細(xì)胞毒性T淋巴細(xì)胞功能失調(diào)。

103.Detecting and quantifying liquid–liquid phase separation in living cells by model-free calibrated half-bleaching.

通過(guò)無(wú)模型校準(zhǔn)的半漂白檢測(cè)和量化活細(xì)胞中的液-液相分離。

104.Hepatic neddylation deficiency triggers fatal liver injury via inducing NF-κB-inducing kinase in mice.

肝臟neddylation缺失通過(guò)誘導(dǎo)小鼠NF-κB誘導(dǎo)性激酶引發(fā)致命的肝損傷。

105.Suppression of flavivirus transmission from animal hosts to mosquitoes with a mosquito-delivered vaccine.

用蚊子遞送的疫苗抑制黃病毒從動(dòng)物宿主到蚊子的傳播。

106.Sequence-specific capture and concentration of viral RNA by type III CRISPR system enhances diagnostic.

III型CRISPR系統(tǒng)對(duì)病毒RNA的序列特異性捕獲和濃縮增強(qiáng)了診斷能力。

107.A signal-like role for floral humidity in a nocturnal pollination system.

花卉濕度在夜間授粉系統(tǒng)中的信號(hào)類(lèi)作用。

108.Achieving single nucleotide sensitivity in direct hybridization genome imaging.

在直接雜交基因組成像中實(shí)現(xiàn)單核苷酸敏感性。

109.Multi-omics identify falling LRRC15 as a COVID-19 severity marker and persistent pro-thrombotic signals in convalescence.

多組學(xué)識(shí)別下降的LRRC15作為COVID-19嚴(yán)重性標(biāo)志物和療養(yǎng)中持續(xù)的促血栓信號(hào)。

110.Sleep-like unsupervised replay reduces catastrophic forgetting in artificial neural networks.

類(lèi)似睡眠的無(wú)監(jiān)督重放減少了人工神經(jīng)網(wǎng)絡(luò)的災(zāi)難性遺忘。

111.A unifying Bayesian framework for merging X-ray diffraction data.

合并X射線衍射數(shù)據(jù)的統(tǒng)一貝葉斯框架。

112.Structural insights into p300 regulation and acetylation-dependent genome organisation.

對(duì)p300調(diào)節(jié)和乙?；蕾?lài)的基因組組織的結(jié)構(gòu)性見(jiàn)解。

113.Bond-selective intensity diffraction tomography.

邦德選擇強(qiáng)度的衍射斷層掃描。

114.Nr6a1 controls Hox expression dynamics and is a master regulator of vertebrate trunk development.

Nr6a1控制Hox表達(dá)動(dòng)態(tài)，是脊椎動(dòng)物軀干發(fā)育的主要調(diào)節(jié)器。

115.Accuracy and data efficiency in deep learning models of protein expression.

蛋白質(zhì)表達(dá)的深度學(xué)習(xí)模型的準(zhǔn)確性和數(shù)據(jù)效率。

116.Estimating diagnostic uncertainty in artificial intelligence assisted pathology using conformal prediction.

利用保形預(yù)測(cè)估計(jì)人工智能輔助病理學(xué)的診斷不確定性.

117.Compact Cas9d and HEARO enzymes for genome editing discovered from uncultivated microbes.

從未培養(yǎng)的微生物中發(fā)現(xiàn)用于基因組編輯的緊湊型Cas9d和HEARO酶。

118.A nigro–subthalamo–parabrachial pathway modulates pain-like behaviors.

黑質(zhì)-下肢-旁肢通路調(diào)控類(lèi)似疼痛的行為。

119.Atomically dispersed golds on degradable zero-valent copper nanocubes augment oxygen driven Fenton-like reaction for effective orthotopic tumor therapy.

可降解零價(jià)銅納米立方體上的原子分散的金子增強(qiáng)了氧驅(qū)動(dòng)的芬頓樣反應(yīng)，用于有效的正位腫瘤治療。

120.Microencapsulation and nanowarming enables vitrification cryopreservation of mouse preantral follicles.

微囊化和納米溫控實(shí)現(xiàn)了小鼠前卵泡的玻璃化冷凍保存。

121.Biosynthesis of mushroom-derived type II ganoderic acids by engineered yeast.

工程酵母的蘑菇源II型靈芝酸的生物合成。

122.In-depth mapping of protein localizations in whole tissue by micro-scaffold assisted spatial proteomics (MASP).

顯微支架輔助空間蛋白質(zhì)組學(xué)（MASP）對(duì)整個(gè)組織中蛋白質(zhì)定位的深入映射。

123.A Mycobacterium tuberculosis fingerprint in human breath allows tuberculosis detection.

人體呼吸中的結(jié)核分枝桿菌指紋可以檢測(cè)結(jié)核病。

124.Exosomal miR-1304-3p promotes breast cancer progression in African Americans by activating cancer-associated adipocytes.

外泌體miR-1304-3p通過(guò)激活癌癥相關(guān)的脂肪細(xì)胞促進(jìn)非裔美國(guó)人乳腺癌的進(jìn)展。

125.Primary exposure to SARS-CoV-2 variants elicits convergent epitope specificities, immunoglobulin V gene usage and public B cell clones.

初次接觸SARS-CoV-2變體可引起趨同的表位特異性、免疫球蛋白V基因使用和公共B細(xì)胞克隆。

126.St18 specifies globus pallidus projection neuron identity in MGE lineage.

St18在MGE系中指定球狀小腦投射神經(jīng)元的身份。

127.Biodiversity–stability relationships strengthen over time in a long-term grassland experiment.

在長(zhǎng)期的草原實(shí)驗(yàn)中，生物多樣性-穩(wěn)定性關(guān)系隨著時(shí)間的推移而加強(qiáng)。

128.Dynamic assembly of DNA-ceria nanocomplex in living cells generates artificial peroxisome.

活細(xì)胞中DNA-鈰納米復(fù)合物的動(dòng)態(tài)組裝產(chǎn)生了人工過(guò)氧化物酶體。

129.Discovery of synthetic lethal interactions from large-scale pan-cancer perturbation screens.

從大規(guī)模泛癌擾動(dòng)篩選中發(fā)現(xiàn)合成致死的相互作用。

130.Structure of the Acidobacteria homodimeric reaction center bound with cytochrome c.

與細(xì)胞色素c結(jié)合的酸桿菌同源反應(yīng)中心的結(jié)構(gòu)。

131.Genetic architecture of heart failure with preserved versus reduced ejection fraction.

保留射血分?jǐn)?shù)與減少射血分?jǐn)?shù)的心力衰竭的遺傳結(jié)構(gòu)。

132.Genome of Paspalum vaginatum and the role of trehalose mediated autophagy in increasing maize biomass.

Paspalum vaginatum的基因組和trehalose介導(dǎo)的自噬在增加玉米生物量中的作用。

133.Deep brain stimulation creates informational lesion through membrane depolarization in mouse hippocampus.

深度腦刺激通過(guò)小鼠海馬體的膜去極化產(chǎn)生信息性病變。

134.Activation of a transient progenitor state in the epicardium is required for zebrafish heart regeneration.

斑馬魚(yú)心臟再生需要激活心外膜的瞬時(shí)祖細(xì)胞狀態(tài)。

135.Histone H3.3 deposition in seed is essential for the post-embryonic developmental competence in Arabidopsis.

種子中組蛋白H3.3的沉積對(duì)擬南芥胚胎后的發(fā)育能力至關(guān)重要。

136.Spatial transcriptomics landscape of lesions from non-communicable inflammatory skin diseases.

非傳染性炎癥性皮膚病病變的空間轉(zhuǎn)錄組學(xué)景觀。

137.BA.2 and BA.5 omicron differ immunologically from both BA.1 omicron and pre-omicron variants.

BA.2和BA.5 omicron與BA.1 omicron和pre-omicron變體的免疫學(xué)差異。

138.Functional crosstalk between the cohesin loader and chromatin remodelers.

協(xié)同蛋白加載器和染色質(zhì)重塑器之間的功能串聯(lián)。

139.CENP-F-dependent DRP1 function regulates APC/C activity during oocyte meiosis I.

CENP-F依賴(lài)的DRP1功能在卵母細(xì)胞減數(shù)分裂I期間調(diào)節(jié)APC/C的活性。

140.Locally organised and activated Fth1hi neutrophils aggravate inflammation of acute lung injury in an IL-10-dependent manner.

局部組織和激活的Fth1hi中性粒細(xì)胞以IL-10依賴(lài)的方式加重急性肺損傷的炎癥。

141.Cell-type specific profiling of histone post-translational modifications in the adult mouse striatum.

成年小鼠紋狀體中組蛋白翻譯后修飾的細(xì)胞類(lèi)型特征分析。

142.Clustering of single-cell multi-omics data with a multimodal deep learning method.

用多模態(tài)深度學(xué)習(xí)方法對(duì)單細(xì)胞多組學(xué)數(shù)據(jù)進(jìn)行聚類(lèi)。

143.Gene augmentation prevents retinal degeneration in a CRISPR/Cas9-based mouse model of PRPF31 retinitis pigmentosa.

基因增強(qiáng)可防止基于CRISPR/Cas9的PRPF31視網(wǎng)膜色素變性小鼠模型中的視網(wǎng)膜變性。

144.Microbiome-mediated fructose depletion restricts murine gut colonization by vancomycin-resistant Enterococcus.

微生物體介導(dǎo)的果糖耗竭限制了耐萬(wàn)古霉素的腸球菌在小鼠腸道的定植。

145.Inferring time-varying generation time, serial interval, and incubation period distributions for COVID-19.

推斷COVID-19的時(shí)變生成時(shí)間、序列間隔和孵化期分布。

146.Structure-function studies reveal ComEA contains an oligomerization domain essential for transformation in gram-positive bacteria.

結(jié)構(gòu)-功能研究顯示ComEA含有一個(gè)對(duì)革蘭氏陽(yáng)性菌轉(zhuǎn)化至關(guān)重要的寡聚結(jié)構(gòu)域。

147.Immunogenicity and efficacy of fourth BNT162b2 and mRNA1273 COVID-19 vaccine doses; three months follow-up.

第四劑BNT162b2和mRNA1273 COVID-19疫苗的免疫原性和療效；三個(gè)月的隨訪。

148.Reported sleep duration reveals segmentation of the adult life-course into three phases.

報(bào)告的睡眠時(shí)間顯示，成人的生命歷程被分割成三個(gè)階段。

149.Condensates formed by prion-like low-complexity domains have small-world network structures and interfaces defined by expanded conformations.

由類(lèi)似朊病毒的低復(fù)雜度域形成的凝集物具有小世界網(wǎng)絡(luò)結(jié)構(gòu)和由擴(kuò)展構(gòu)象定義的界面。

150.Tumor fractions deciphered from circulating cell-free DNA methylation for cancer early diagnosis.

從循環(huán)無(wú)細(xì)胞DNA甲基化解讀腫瘤部分，用于癌癥早期診斷。

151.Anomalous inapplicability of nacre-like architectures as impact-resistant templates in a wide range of impact velocities.

在廣泛的沖擊速度下，珍珠狀結(jié)構(gòu)作為抗沖擊模板的異常不適用性。

152.Sex differences in allometry for phenotypic traits in mice indicate that females are not scaled males.

小鼠表型性狀的異體測(cè)量的性別差異表明，雌性不是按比例的雄性。

153.Broad misappropriation of developmental splicing profile by cancer in multiple organs.

癌癥在多個(gè)器官中廣泛挪用發(fā)育剪接譜。

154.Dynamics of extended-spectrum cephalosporin resistance genes in Escherichia coli from Europe and North America.

歐洲和北美大腸桿菌中延伸譜系頭孢菌素抗性基因的動(dòng)態(tài)變化。

155.Regulation of bone homeostasis by MERTK and TYRO3.

MERTK和TYRO3對(duì)骨質(zhì)平衡的調(diào)節(jié)。

156.Tagging active neurons by soma-targeted Cal-Light.

以體細(xì)胞為目標(biāo)的Cal-Light標(biāo)記活性神經(jīng)元.

157.Deep transfer learning enables lesion tracing of circulating tumor cells.

深度遷移學(xué)習(xí)實(shí)現(xiàn)了循環(huán)腫瘤細(xì)胞的病變追蹤。

158.PEAC-seq adopts Prime Editor to detect CRISPR off-target and DNA translocation.

PEAC-seq采用Prime Editor檢測(cè)CRISPR脫靶和DNA易位。

159.An atlas of late prenatal human neurodevelopment resolved by single-nucleus transcriptomics.

通過(guò)單核轉(zhuǎn)錄組學(xué)解決產(chǎn)前晚期人類(lèi)神經(jīng)發(fā)育的圖譜。

160.Phenome-wide association study of loci harboring de novo tandem repeat mutations in UK Biobank exomes.

英國(guó)生物庫(kù)外顯子中攜帶新的串聯(lián)重復(fù)突變的位點(diǎn)的全表型關(guān)聯(lián)研究。

161.Different roles of concurring climate and regional land-use changes in past 40 years’ insect trends.

氣候和區(qū)域土地利用變化在過(guò)去40年的昆蟲(chóng)趨勢(shì)中的不同作用。

162.Structural mechanism of signal transduction in a phytochrome histidine kinase.

植物色素組氨酸激酶中信號(hào)轉(zhuǎn)導(dǎo)的結(jié)構(gòu)機(jī)制。

163.Ocular tropism of SARS-CoV-2 in animal models with retinal inflammation via neuronal invasion following intranasal inoculation.

SARS-CoV-2在動(dòng)物模型中的眼球趨向性，通過(guò)鼻內(nèi)接種后的神經(jīng)元侵襲引起視網(wǎng)膜炎癥。

164.Molecular models of multiple sclerosis severity identify heterogeneity of pathogenic mechanisms.

多發(fā)性硬化癥嚴(yán)重程度的分子模型確定致病機(jī)制的異質(zhì)性。

165.Bioenergetic control of soil carbon dynamics across depth.

跨越深度的土壤碳動(dòng)力學(xué)的生物能量控制。

166.SIRT7 suppresses energy expenditure and thermogenesis by regulating brown adipose tissue functions in mice.

SIRT7通過(guò)調(diào)控小鼠棕色脂肪組織功能抑制能量消耗和產(chǎn)熱。

167.PRDM1/BLIMP1 induces cancer immune evasion by modulating the USP22-SPI1-PD-L1 axis in hepatocellular carcinoma cells.

PRDM1/BLIMP1通過(guò)調(diào)節(jié)肝癌細(xì)胞的USP22-SPI1-PD-L1軸誘導(dǎo)癌癥免疫規(guī)避。

168.Brain metastatic outgrowth and osimertinib resistance are potentiated by RhoA in EGFR-mutant lung cancer.

在EGFR突變的肺癌中，RhoA增強(qiáng)了腦轉(zhuǎn)移的生長(zhǎng)和奧希姆替尼的抗性。

169.Effectiveness of ChAdOx1-S COVID-19 booster vaccination against the Omicron and Delta variants in England.

英國(guó)ChAdOx1-S COVID-19加強(qiáng)型疫苗對(duì)Omicron和Delta變種的有效性。

170.A widely distributed family of eukaryotic and bacterial deubiquitinases related to herpesviral large tegument proteins.

一個(gè)廣泛分布的真核生物和細(xì)菌去泛素酶家族，與皰疹病毒大包膜蛋白有關(guān)。

171.Cryo-electron tomography reveals structural insights into the membrane remodeling mode of dynamin-like EHD filaments.

Cryo-electron tomography揭示了對(duì)Dynamin-like EHD filaments的膜重塑模式的結(jié)構(gòu)見(jiàn)解。

172.Myeloid cells promote interferon signaling-associated deterioration of the hematopoietic system.

髓細(xì)胞促進(jìn)干擾素信號(hào)相關(guān)的造血系統(tǒng)的惡化。

173.A glutamate receptor C-tail recruits CaMKII to suppress retrograde homeostatic signaling.

一個(gè)谷氨酸受體的C-尾巴招募CaMKII以抑制逆行的同源信號(hào)。

174.Activating alternative transport modes in a multidrug resistance efflux pump to confer chemical susceptibility.

激活多藥耐藥性外排泵的替代運(yùn)輸模式，以賦予化學(xué)藥敏性。

175.The B-type response regulator GmRR11d mediates systemic inhibition of symbiotic nodulation.

B型反應(yīng)調(diào)節(jié)器GmRR11d介導(dǎo)了對(duì)共生結(jié)核的系統(tǒng)性抑制。

176.Structure of nucleosome-bound human PBAF complex.

核糖體結(jié)合的人類(lèi)PBAF復(fù)合物的結(jié)構(gòu)。

177.Targeting cardiomyocyte ADAM10 ectodomain shedding promotes survival early after myocardial infarction.

靶向心肌細(xì)胞ADAM10外域脫落促進(jìn)心肌梗死后早期生存。

178.A multi-phenotype analysis reveals 19 susceptibility loci for basal cell carcinoma and 15 for squamous cell carcinoma.

多表型分析揭示了基底細(xì)胞癌的19個(gè)易感位點(diǎn)和鱗狀細(xì)胞癌的15個(gè)易感位點(diǎn)。

179.Causal inference in medical records and complementary systems pharmacology for metformin drug repurposing towards dementia.

醫(yī)療記錄中的因果推斷和互補(bǔ)系統(tǒng)藥理學(xué)用于二甲雙胍藥物再利用，面向癡呆癥。

180.CRL2ZER1/ZYG11B recognizes small N-terminal residues for degradation.

CRL2ZER1/ZYG11B識(shí)別小的N端殘基進(jìn)行降解。

181.An HSV-1-H129 amplicon tracer system for rapid and efficient monosynaptic anterograde neural circuit tracing.

HSV-1-H129擴(kuò)增子示蹤系統(tǒng)用于快速、高效的單突觸前向神經(jīng)回路追蹤。

182.Sirt6 attenuates chondrocyte senescence and osteoarthritis progression.

Sirt6減弱軟骨細(xì)胞的衰老和骨關(guān)節(jié)炎的進(jìn)展。

183.Single-cell profiling of healthy human kidney reveals features of sex-based transcriptional programs and tissue-specific immunity.

健康人類(lèi)腎臟的單細(xì)胞分析揭示了基于性別的轉(zhuǎn)錄程序和組織特異性免疫的特征。

184.Spatial-ID: a cell typing method for spatially resolved transcriptomics via transfer learning and spatial embedding.

Spatial-ID：一種通過(guò)轉(zhuǎn)移學(xué)習(xí)和空間嵌入進(jìn)行空間解析轉(zhuǎn)錄組學(xué)的細(xì)胞分型方法。

185.A brown fat-enriched adipokine Adissp controls adipose thermogenesis and glucose homeostasis.

一種富含棕色脂肪的脂肪因子Adissp控制脂肪生熱和葡萄糖穩(wěn)態(tài)。

186.Mitochondrial dysfunction induces ALK5-SMAD2-mediated hypovascularization and arteriovenous malformations in mouse retinas.

線粒體功能障礙誘導(dǎo)小鼠視網(wǎng)膜中ALK5-SMAD2介導(dǎo)的血管減退和動(dòng)靜脈畸形。

187.The establishment of COPD organoids to study host-pathogen interaction reveals enhanced viral fitness of SARS-CoV-2 in bronchi.

建立COPD器官來(lái)研究宿主與病原體的相互作用，揭示了SARS-CoV-2在支氣管中的病毒適應(yīng)性增強(qiáng)。

188.Regulating voltage-gated ion channels with nanobodies.

用納米抗體調(diào)節(jié)電壓門(mén)控離子通道。

189.Maturation and specialization of group 2 innate lymphoid cells through the lung-gut axis.

第2組先天性淋巴細(xì)胞通過(guò)肺-腸軸的成熟和特化。

190.Visualizing the transiently populated closed-state of human HSP90 ATP binding domain.

可視化人類(lèi)HSP90 ATP結(jié)合域的瞬時(shí)填充封閉狀態(tài)。

191.Interpretable and tractable models of transcriptional noise for the rational design of single-molecule quantification experiments.

用于合理設(shè)計(jì)單分子定量實(shí)驗(yàn)的可解釋和可操作的轉(zhuǎn)錄噪音模型。

192.The transcription factor DDIT3 is a potential driver of dyserythropoiesis in myelodysplastic syndromes.

轉(zhuǎn)錄因子DDIT3是骨髓增生異常綜合征中紅細(xì)胞生成障礙的一個(gè)潛在驅(qū)動(dòng)因素。

193.Selective posttranslational inhibition of CaVβ1-associated voltage-dependent calcium channels with a functionalized nanobody.

用功能化納米抗體對(duì)CaVβ1相關(guān)電壓依賴(lài)性鈣通道進(jìn)行選擇性翻譯后抑制。

194.High-throughput robust single-cell DNA methylation profiling with sciMETv2.

sciMETv2的高通量單細(xì)胞DNA甲基化分析。

195.Structure of the AlgKX modification and secretion complex required for alginate production and biofilm attachment in Pseudomonas aeruginosa.

銅綠假單胞菌海藻酸鹽生產(chǎn)和生物膜附著所需的AlgKX修飾和分泌復(fù)合物的結(jié)構(gòu)。

196.Limited conservation in cross-species comparison of GLK transcription factor binding suggested wide-spread cistrome divergence.

在GLK轉(zhuǎn)錄因子結(jié)合的跨物種比較中，有限的保護(hù)表明了廣泛的組群分化。

197.Suicidal chemotaxis in bacteria.

細(xì)菌的自殺性趨化作用。

198.SARS-CoV-2 Spike triggers barrier dysfunction and vascular leak via integrins and TGF-β signaling.

SARS-CoV-2穗狀病毒通過(guò)整合素和TGF-β信號(hào)傳導(dǎo)引發(fā)屏障功能障礙和血管滲漏。

199.Immunogenetic losses co-occurred with seahorse male pregnancy and mutation in tlx1 accompanied functional asplenia.

免疫基因損失與海馬雄性懷孕同時(shí)發(fā)生，tlx1的突變伴隨著功能性無(wú)脾癥。

200.TBX2 specifies and maintains inner hair and supporting cell fate in the Organ of Corti.

TBX2指定并維持內(nèi)毛和支持細(xì)胞在科爾蒂器官的命運(yùn)。

201.Noradrenergic signaling mediates cortical early tagging and storage of remote memory.

北腎上腺素能信號(hào)介導(dǎo)皮質(zhì)早期標(biāo)記和遠(yuǎn)程記憶的存儲(chǔ)。

202.Engineering antiviral immune-like systems for autonomous virus detection and inhibition in mice.

在小鼠中自主檢測(cè)和抑制病毒的抗病毒免疫系統(tǒng)工程。

203.Parvalbumin basket cell myelination accumulates axonal mitochondria to internodes.

副白蛋白籃細(xì)胞髓鞘化將軸突線粒體積累到節(jié)間。

204.Genetic manipulation of the human gut bacterium Eggerthella lenta reveals a widespread family of transcriptional regulators.

對(duì)人類(lèi)腸道細(xì)菌Eggerthella lenta的遺傳操作揭示了一個(gè)廣泛的轉(zhuǎn)錄調(diào)節(jié)器家族。

205.Structural basis for a human broadly neutralizing influenza A hemagglutinin stem-specific antibody including H17/18 subtypes.

包括H17/18亞型在內(nèi)的人類(lèi)廣泛中和甲型流感血凝素干細(xì)胞特異性抗體的結(jié)構(gòu)基礎(chǔ)。

206.Allosteric rescue of catalytically impaired ATP phosphoribosyltransferase variants links protein dynamics to active-site electrostatic preorganisation.

催化受損的ATP磷酸核苷轉(zhuǎn)移酶變體的異生拯救將蛋白質(zhì)動(dòng)力學(xué)與活性位點(diǎn)靜電預(yù)組織聯(lián)系起來(lái)。

207.Meteorin-like is an injectable peptide that can enhance regeneration in aged muscle through immune-driven fibro/adipogenic progenitor signaling.

Meteorin-like是一種可注射的肽，可以通過(guò)免疫驅(qū)動(dòng)的纖維/脂肪生成祖細(xì)胞信號(hào)來(lái)增強(qiáng)老年肌肉的再生能力。

208.Identifying antibiotics based on structural differences in the conserved allostery from mitochondrial heme-copper oxidases.

基于線粒體血銅氧化酶的保守異構(gòu)體的結(jié)構(gòu)差異識(shí)別抗生素。

209.An RNA sponge controls quorum sensing dynamics and biofilm formation in Vibrio cholerae.

一種RNA海綿控制霍亂弧菌的法定人數(shù)感應(yīng)動(dòng)態(tài)和生物膜的形成。

210.Recent speciation associated with range expansion and a shift to self-fertilization in North American Arabidopsis.

與北美擬南芥的范圍擴(kuò)張和向自花授精轉(zhuǎn)變有關(guān)的最近的物種變化。

211.Intracellular galectin-3 is a lipopolysaccharide sensor that promotes glycolysis through mTORC1 activation.

細(xì)胞內(nèi)galectin-3是一種脂多糖傳感器，通過(guò)mTORC1的激活促進(jìn)糖酵解。

212.Whole genome sequencing identifies structural variants contributing to hematologic traits in the NHLBI TOPMed program.

在NHLBI TOPMed計(jì)劃中，全基因組測(cè)序確定了有助于血液學(xué)特征的結(jié)構(gòu)變異。

213.Conserved degronome features governing quality control associated proteolysis.

掌管質(zhì)量控制相關(guān)的蛋白質(zhì)分解的保守的degronome特征。

214.Discovery and structure of a widespread bacterial ABC transporter specific for ergothioneine.

發(fā)現(xiàn)了一個(gè)廣泛的細(xì)菌ABC轉(zhuǎn)運(yùn)體，其結(jié)構(gòu)對(duì)麥角硫因具有特異性。

215.Divergent self-association properties of paralogous proteins TRIM2 and TRIM3 regulate their E3 ligase activity.

同源蛋白TRIM2和TRIM3的不同自我關(guān)聯(lián)屬性調(diào)節(jié)其E3連接酶的活性。

216.Differential IL18 signaling via IL18 receptor and Na-Cl co-transporter discriminating thermogenesis and glucose metabolism regulation.

通過(guò)IL18受體和Na-Cl共轉(zhuǎn)運(yùn)體的不同IL18信號(hào)傳遞區(qū)分了產(chǎn)熱和葡萄糖代謝的調(diào)節(jié)。

217.Neural precursor cells tune striatal connectivity through the release of IGFBPL1.

神經(jīng)前體細(xì)胞通過(guò)釋放IGFBPL1調(diào)控紋狀體的連接性。

218.Slow growing behavior in African trypanosomes during adipose tissue colonization.

非洲錐蟲(chóng)在脂肪組織定植期間的緩慢生長(zhǎng)行為。

219.The protein phosphatase 2A holoenzyme is a key regulator of starch metabolism and bradyzoite differentiation in Toxoplasma gondii.

蛋白磷酸酶2A全酶是弓形蟲(chóng)的淀粉代謝和鹵蟲(chóng)分化的關(guān)鍵調(diào)節(jié)因子。

220.The role of the tryptophan-NAD?+?pathway in a mouse model of severe malnutrition induced liver dysfunction.

色氨酸-NAD+途徑在嚴(yán)重營(yíng)養(yǎng)不良誘發(fā)肝功能障礙的小鼠模型中的作用。

221.Identification of human progenitors of exhausted CD8+ T cells associated with elevated IFN-γ response in early phase of viral infection.

鑒定與病毒感染早期階段IFN-γ反應(yīng)升高有關(guān)的人類(lèi)衰竭CD8+T細(xì)胞的祖先。

222.Multiregional single-cell dissection of tumor and immune cells reveals stable lock-and-key features in liver cancer.

腫瘤和免疫細(xì)胞的多區(qū)域單細(xì)胞剖析揭示了肝癌的穩(wěn)定鎖定特征。

223.pGlycoQuant with a deep residual network for quantitative glycoproteomics at intact glycopeptide level.

pGlycoQuant與深度殘留網(wǎng)絡(luò)，用于完整糖肽水平的定量糖蛋白組學(xué)。

224.CD1a promotes systemic manifestations of skin inflammation.

CD1a促進(jìn)皮膚炎癥的系統(tǒng)性表現(xiàn)。

225.Breast cancer prevention by short-term inhibition of TGFβ signaling.

通過(guò)短期抑制TGFβ信號(hào)傳導(dǎo)預(yù)防乳腺癌.

226.Phosphoproteomic analysis of neoadjuvant breast cancer suggests that increased sensitivity to paclitaxel is driven by CDK4 and filamin A.

新輔助性乳腺癌的磷蛋白組學(xué)分析表明，對(duì)紫杉醇敏感性的增加是由CDK4和filamin A驅(qū)動(dòng)的。

227.GABAergic neurons in the rostromedial tegmental nucleus are essential for rapid eye movement sleep suppression.

頭內(nèi)側(cè)被蓋核的GABA能神經(jīng)元對(duì)快速眼動(dòng)睡眠抑制至關(guān)重要。

228.Epithelial TGFβ engages growth-factor signalling to circumvent apoptosis and drive intestinal tumourigenesis with aggressive features.

上皮細(xì)胞TGFβ參與生長(zhǎng)因子信號(hào)以規(guī)避細(xì)胞凋亡并驅(qū)動(dòng)具有攻擊性特征的腸道腫瘤發(fā)生。

229.Population fluctuations and synanthropy explain transmission risk in rodent-borne zoonoses.

種群波動(dòng)和協(xié)同作用解釋了嚙齒動(dòng)物傳染病的傳播風(fēng)險(xiǎn)。

230.An in silico method to assess antibody fragment polyreactivity.

一種評(píng)估抗體片段多反應(yīng)性的硅方法

231.Quantifying the role of transcript levels in mediating DNA methylation effects on complex traits and diseases.

量化轉(zhuǎn)錄物水平在介導(dǎo)DNA甲基化對(duì)復(fù)雜性狀和疾病影響中的作用。

232.Deconstruction of a hypothalamic astrocyte-white adipocyte sympathetic axis that regulates lipolysis in mice.

解構(gòu)調(diào)節(jié)小鼠脂肪分解的下丘腦星形細(xì)胞-白脂肪細(xì)胞交感神經(jīng)軸。

233.Dynamic control of decision and movement speed in the human basal ganglia.

人類(lèi)基底神經(jīng)節(jié)對(duì)決策和運(yùn)動(dòng)速度的動(dòng)態(tài)控制。

234.Structural basis for the non-self RNA-activated protease activity of the type III-E CRISPR nuclease-protease Craspase.

III-E型CRISPR核酸酶-蛋白酶Craspase的非自身RNA激活蛋白酶活性的結(jié)構(gòu)基礎(chǔ)。

235.The estrous cycle modulates early-life adversity effects on mouse avoidance behavior through progesterone signaling.

發(fā)情周期通過(guò)孕酮信號(hào)調(diào)節(jié)早期生活逆境對(duì)小鼠回避行為的影響。

236.Backbone amides are determinants of Cl? selectivity in CLC ion channels.

骨架酰胺是CLC離子通道中Cl-選擇性的決定因素。

237.SESAME-catalyzed H3T11 phosphorylation inhibits Dot1-catalyzed H3K79me3 to regulate autophagy and telomere silencing.

SESAME催化的H3T11磷酸化抑制了Dot1催化的H3K79me3以調(diào)節(jié)自噬和端粒沉默。

238.The role of auxiliary domains in modulating CHD4 activity suggests mechanistic commonality between enzyme families.

輔助結(jié)構(gòu)域在調(diào)控CHD4活性方面的作用表明酶家族之間的機(jī)制共性。

239.Increases in reef size, habitat and metacommunity complexity associated with Cambrian radiation oxygenation pulses.

與寒武紀(jì)輻射含氧量脈沖有關(guān)的珊瑚礁規(guī)模、生境和元群落復(fù)雜性的增加。

240.New globally distributed bacterial phyla within the FCB superphylum.

FCB超門(mén)內(nèi)新的全球分布的細(xì)菌門(mén)類(lèi)。

241.Multiple drivers and lineage-specific insect extinctions during the Permo–Triassic.

在近三疊紀(jì)期間，多種驅(qū)動(dòng)因素和特定品系的昆蟲(chóng)滅絕。

242.Characterization of an RNA binding protein interactome reveals a context-specific post-transcriptional landscape of MYC-amplified medulloblastoma.

RNA結(jié)合蛋白相互作用組的特征揭示了MYC擴(kuò)增的髓母細(xì)胞瘤的背景特異性轉(zhuǎn)錄后景觀。

243.DAP5 enables main ORF translation on mRNAs with structured and uORF-containing 5′ leaders.

DAP5使具有結(jié)構(gòu)化和含uORF的5′領(lǐng)導(dǎo)的mRNA上的主ORF翻譯。

244.Slowest possible replicative life at frigid temperatures for yeast.

酵母在低溫下可能的最慢復(fù)制生命。

245.The dynamic clustering of insulin receptor underlies its signaling and is disrupted in insulin resistance.

胰島素受體的動(dòng)態(tài)集群是其信號(hào)傳導(dǎo)的基礎(chǔ)，在胰島素抵抗中被破壞。

246.Gut microbiome-wide association study of depressive symptoms.

抑郁癥狀的全腸道微生物組關(guān)聯(lián)研究。

247.Food abundance in men before puberty predicts a range of cancers in grandsons.

青春期前男性的食物豐度可預(yù)測(cè)孫子的一系列癌癥。

248.Next generation genetically encoded fluorescent sensors for serotonin.

下一代5-羥色胺的基因編碼熒光傳感器。

249.Ruminant inner ear shape records 35 million years of neutral evolution.

反芻動(dòng)物內(nèi)耳形狀記錄了3500萬(wàn)年的中性進(jìn)化。

250.LY6D marks pre-existing resistant basosquamous tumor subpopulations.

LY6D標(biāo)記預(yù)先存在的抗性基底細(xì)胞腫瘤亞群。

251.The gut microbiota and depressive symptoms across ethnic groups.

腸道微生物群和不同種族群體的抑郁癥狀。

252.The overlapping burden of the three leading causes of disability and death in sub-Saharan African children.

撒哈拉以南非洲兒童殘疾和死亡的三個(gè)主要原因的重疊負(fù)擔(dān)。

253.Cannabinoid non-cannabidiol site modulation of TRPV2 structure and function.

TRPV2?結(jié)構(gòu)和功能的大麻素非大麻二酚位點(diǎn)調(diào)制。

254.Planar aggregation of the influenza viral fusion peptide alters membrane structure and hydration, promoting poration.

流感病毒融合肽的平面聚集改變了膜結(jié)構(gòu)和水合作用，促進(jìn)了孔化。

255.SepN is a septal junction component required for gated cell–cell communication in the filamentous cyanobacterium Nostoc.

SepN是絲狀藍(lán)藻中門(mén)控細(xì)胞-細(xì)胞通訊所需的隔膜連接組件。

256.The circadian clock influences T cell responses to vaccination by regulating dendritic cell antigen processing.

晝夜鐘通過(guò)調(diào)控樹(shù)突狀細(xì)胞抗原處理影響T細(xì)胞對(duì)疫苗接種的反應(yīng)。

257.Structural basis of sequence-specific RNA recognition by the antiviral factor APOBEC3G.

抗病毒因子APOBEC3G識(shí)別序列特異性RNA的結(jié)構(gòu)基礎(chǔ)。

258.Single-cell sequencing shows cellular heterogeneity of cutaneous lesions in lupus erythematosus.

單細(xì)胞測(cè)序顯示紅斑狼瘡皮膚病變的細(xì)胞異質(zhì)性。

259.Proteogenomic characterization of MiT family translocation renal cell carcinoma.

MiT家族易位腎細(xì)胞癌的蛋白質(zhì)基因組學(xué)特征。

260.Pexophagy suppresses ROS-induced damage in leaf cells under high-intensity light.

Pexophagy抑制高強(qiáng)度光照下葉細(xì)胞的ROS誘導(dǎo)損傷。

261.Genome-wide association study of REM sleep behavior disorder identifies polygenic risk and brain expression effects.

快速眼動(dòng)睡眠行為障礙的全基因組關(guān)聯(lián)研究確定了多基因風(fēng)險(xiǎn)和大腦表達(dá)效應(yīng)。

262.Impact of international travel and diarrhea on gut microbiome and resistome dynamics.

國(guó)際旅行和腹瀉對(duì)腸道微生物組和抗性組動(dòng)態(tài)的影響。

263.Tissue and liquid biopsy profiling reveal convergent tumor evolution and therapy evasion in breast cancer.

組織和液體活檢分析揭示了乳腺癌中趨同的腫瘤演變和治療規(guī)避。

264.Federated learning enables big data for rare cancer boundary detection.

聯(lián)合學(xué)習(xí)使大數(shù)據(jù)用于罕見(jiàn)癌癥邊界檢測(cè)。

265.Single-shot self-supervised object detection in microscopy.

顯微鏡下的單次自監(jiān)督物體檢測(cè)。

266.Self-assembling nanofibrous bacteriophage microgels as sprayable antimicrobials targeting multidrug-resistant bacteria.

自組裝的納米纖維狀噬菌體微凝膠作為可噴涂的抗菌劑，針對(duì)多藥耐藥菌。

================================

由于字?jǐn)?shù)限制，關(guān)注我的個(gè)人公眾號(hào)”遠(yuǎn)夢(mèng)研“查看更多。