國際獸醫(yī)癲癇工作組共識建議：歐洲犬癲癇的藥物治療

Sofie F.M. Bhatti1*, Luisa De Risio2 , Karen Mu?ana3 , Jacques Penderis4 , Veronika M. Stein5 , Andrea Tipold5 , Mette Berendt6 , Robyn G. Farquhar7 , Andrea Fischer8 , Sam Long9 , Wolfgang L?scher10, Paul J.J. Mandigers11, Kaspar Matiasek12, Akos Pakozdy13, Edward E. Patterson14, Simon Platt15, Michael Podell16, Heidrun Potschka17, Clare Rusbridge18,19 and Holger A. Volk20?

翻譯 By @蘇蘇蘇蘇喬

校正 By @寵物神經(jīng)科醫(yī)生高健

Pet owner education
寵主教育

In order to promote a successful management of an epileptic pet, owners need to be educated thoroughly on[23, 32, 91]:

為了促進癲癇寵物病情控制的成功，需要對寵主進行徹底的教育[23,32,91]:

• The disease of their pet and the influence on their daily life (considerations regarding e.g. leaving the dog alone, what to do if travelling and leaving the dog in a kennel, fears of behavioural comorbidities, …)

• The need for AED therapy and the understanding that this often is a lifetime commitment

• The aim of AED therapy

• The importance of regular administration of AEDs

• The fact that dose adjustments should only be made after consulting a veterinarian – Potential adverse effects of AED therapy

• The importance of maintaining a detailed seizure diary

• The importance of regular check-ups to monitor AED blood concentrations as well as haematology/serum biochemistry where appropriate

• The need for treatment modulation to achieve optimal seizure control – The possibility of occurrence of status epilepticus and cluster seizures and the administration of additional AEDs at home

• Costs involved

• The fact that drug interactions might occur when combined with other AEDs or non-AEDs

• The understanding that abrupt drug withdrawal might be detrimental

• The fact that diet (e.g salt content), diarrhoea and vomiting may affect the absorption of AEDs. It should be advised to keep the diet constant or to make changes gradually and seek veterinary advice if gastrointestinal signs occur.

• 寵物的疾病及其對他們?nèi)粘Ｉ畹挠绊懀ɡ?，考慮讓犬獨處，如果旅行和把犬留在犬舍時該怎么做，對行為學并發(fā)癥的恐懼……）

• 對抗癲癇藥物治療的需求，并認識到這往往需要保證終身服藥

• 抗癲癇藥物治療的目的

• 定期規(guī)律使用抗癲癇藥物的重要性

• 只有在咨詢獸醫(yī)后才能調(diào)整劑量

• 抗癲癇藥物治療的潛在不良影響

• 記錄詳細的抽搐發(fā)作日志的重要性

• 定期復查以監(jiān)測抗癲癇藥物血液濃度以及血液學/血清生化的重要性

• 調(diào)整治療方式以達到最佳的抽搐控制的需求

• 發(fā)生癲癇持續(xù)狀態(tài)和叢集性抽搐發(fā)作的可能性，以及如何在家中使用額外的抗癲癇藥物

• 所涉及的花費

• 藥物與其他抗癲癇藥物或非抗癲癇藥物合用時可能發(fā)生相互作用的事實

• 認識到突然停藥可能是致命性的

• 飲食（例如含鹽量）、腹瀉和嘔吐可能影響抗癲癇藥物的吸收。 應建議保持飲食不變或逐漸改變，如果出現(xiàn)胃腸道癥狀，應尋求獸醫(yī)的建議。