聲明：本專欄主要對(duì)生命科學(xué)領(lǐng)域的一些期刊文章標(biāo)題進(jìn)行翻譯，所有內(nèi)容均由本人手工整理翻譯。由于本人專業(yè)為生物分析相關(guān)，其他領(lǐng)域如果出現(xiàn)翻譯錯(cuò)誤請(qǐng)諒解。

1.Regulation of chromatin accessibility by the histone chaperone CAF-1 sustains lineage fidelity.

組蛋白伴侶CAF-1對(duì)染色質(zhì)可及性的調(diào)控維持了血統(tǒng)的忠實(shí)性。

2.Molecular basis of antibiotic self-resistance in a bee larvae pathogen.

蜜蜂幼蟲病原體的抗生素自我抵抗的分子基礎(chǔ)。

3.Knowledge integration and decision support for accelerated discovery of antibiotic resistance genes.

加速發(fā)現(xiàn)抗生素耐藥基因的知識(shí)整合和決策支持。

4.Comprehensive profiling of 1015 patients’ exomes reveals genomic-clinical associations in colorectal cancer.

對(duì)1015名患者外顯子組的綜合分析揭示了結(jié)直腸癌的基因組-臨床關(guān)聯(lián)。

5.Mechanism of integrin activation by talin and its cooperation with kindlin.

Talin激活整合素的機(jī)制及其與kindlin的合作。

6.CFTR mRNAs with nonsense codons are degraded by the SMG6-mediated endonucleolytic decay pathway.

具有無(wú)義密碼子的CFTR mRNA被SMG6介導(dǎo)的核酸內(nèi)切降解途徑所降解。

7.Mitofusin 1 and 2 regulation of mitochondrial DNA content is a critical determinant of glucose homeostasis.

Mitofusin 1和2對(duì)線粒體DNA含量的調(diào)節(jié)是決定葡萄糖平衡的一個(gè)關(guān)鍵因素。

8.In crystallo observation of three metal ion promoted DNA polymerase misincorporation.

在晶體中觀察到三種金屬離子促進(jìn)了?DNA?聚合酶的錯(cuò)誤摻入。

9.Reference-free cell type deconvolution of multi-cellular pixel-resolution spatially resolved transcriptomics data.

多細(xì)胞像素空間分辨率轉(zhuǎn)錄組學(xué)數(shù)據(jù)的無(wú)參考細(xì)胞類型去卷積。

10.Radical SAM-dependent ether crosslink in daropeptide biosynthesis.

達(dá)羅肽生物合成中依賴SAM的自由基醚交聯(lián)。

11.Trends and associated factors for Covid-19 hospitalisation and fatality risk in 2.3 million adults in England.

英國(guó)230萬(wàn)成年人Covid-19住院和死亡風(fēng)險(xiǎn)的趨勢(shì)和相關(guān)因素。

12.Periodic formation of epithelial somites from human pluripotent stem cells.

來(lái)自人類多能干細(xì)胞的上皮體細(xì)胞的周期性形成。

13.Hypoxia-activated neuropeptide Y/Y5 receptor/RhoA pathway triggers chromosomal instability and bone metastasis in Ewing sarcoma.

低氧激活的神經(jīng)肽Y/Y5受體/RhoA途徑引發(fā)尤文肉瘤的染色體不穩(wěn)定和骨轉(zhuǎn)移。

14.A reversibly gated protein-transporting membrane channel made of DNA.

一個(gè)由DNA組成的可逆門控的蛋白質(zhì)運(yùn)輸膜通道。

15.Deficiency in coatomer complex I causes aberrant activation of STING signalling.

衣殼復(fù)合物I的缺陷導(dǎo)致STING信號(hào)的反常激活。

16.Synthetic cells with self-activating optogenetic proteins communicate with natural cells.

具有自激活光遺傳蛋白的合成細(xì)胞與天然細(xì)胞溝通。

17.ERK1/2 is an ancestral organising signal in spiral cleavage.

ERK1/2是螺旋裂解的祖先組織信號(hào)。

18.Evolution of the murine gut resistome following broad-spectrum antibiotic treatment.

廣譜抗生素治療后小鼠腸道抗性組的進(jìn)化。

19.Metabolic preference assay for rapid diagnosis of bloodstream infections.

用于快速診斷血流感染的代謝偏好測(cè)定。

20.Somatic whole genome dynamics of precancer in Barrett’s esophagus reveals features associated with disease progression.

巴雷特食道癌前病變的體細(xì)胞全基因組動(dòng)力學(xué)揭示了與疾病進(jìn)展相關(guān)的特征。

21.A deep siamese neural network improves metagenome-assembled genomes in microbiome datasets across different environments.

深度連體神經(jīng)網(wǎng)絡(luò)改善了不同環(huán)境中微生物組數(shù)據(jù)集的元基因組。

22.An energizing role for motivation in information-seeking during the early phase of the COVID-19 pandemic.

在COVID-19大流行病的早期階段，動(dòng)機(jī)在信息搜索中發(fā)揮著活力。

23.TGS1 mediates 2,2,7-trimethyl guanosine capping of the human telomerase RNA to direct telomerase dependent telomere maintenance.

TGS1介導(dǎo)人類端粒酶RNA的2,2,7-三甲基鳥苷蓋帽，以指導(dǎo)端粒酶依賴性端粒維護(hù)。

24.Glycaemic control is associated with SARS-CoV-2 breakthrough infections in vaccinated patients with type 2 diabetes.

血糖控制與2型糖尿病疫苗患者的SARS-CoV-2突破性感染有關(guān)。

25.Magnesium galvanic cells produce hydrogen and modulate the tumor microenvironment to inhibit cancer growth.

電化鎂細(xì)胞產(chǎn)生氫氣并調(diào)節(jié)腫瘤微環(huán)境以抑制癌癥生長(zhǎng)。

26.Kidney epithelial cells are active mechano-biological fluid pumps.

腎臟上皮細(xì)胞是活躍的機(jī)械-生物流體泵。

27.Structural insights into TRPV2 activation by small molecules.

對(duì)小分子激活TRPV2的結(jié)構(gòu)性見解。

28.Kronos scRT: a uniform framework for single-cell replication timing analysis.

Kronos scRT：一個(gè)用于單細(xì)胞復(fù)制時(shí)間分析的統(tǒng)一框架。

29.Allogeneic TCRαβ deficient CAR T-cells targeting CD123 in acute myeloid leukemia.

異體TCRαβ缺陷的CAR T細(xì)胞靶向CD123在急性骨髓性白血病中的應(yīng)用.

30.Molecular and functional heterogeneity in dorsal and ventral oligodendrocyte progenitor cells of the mouse forebrain in response to DNA damage.

小鼠前腦背側(cè)和腹側(cè)少突膠質(zhì)細(xì)胞祖細(xì)胞對(duì)DNA損傷反應(yīng)的分子和功能異質(zhì)性。

31.Evanescent scattering imaging of single protein binding kinetics and DNA conformation changes.

單一蛋白結(jié)合動(dòng)力學(xué)和DNA構(gòu)象變化的Evanescent?散射成像。

32.Teneurins assemble into presynaptic nanoclusters that promote synapse formation via postsynaptic non-teneurin ligands.

Teneurins組裝成突觸前納米團(tuán)，通過(guò)突觸后非Teneurins配體促進(jìn)突觸形成。

33.Crystal structures and insights into precursor tRNA 5’-end processing by prokaryotic minimal protein-only RNase P.

原核生物最小蛋白R(shí)Nase P的晶體結(jié)構(gòu)和對(duì)前體tRNA 5'端處理的見解。

34.A theory of cortical map formation in the visual brain.

視覺(jué)大腦中皮質(zhì)地圖形成的理論。

35.Targeting CD123 in blastic plasmacytoid dendritic cell neoplasm using allogeneic anti-CD123 CAR T cells.

使用異體抗CD123的CAR T細(xì)胞靶向母細(xì)胞性漿細(xì)胞樣樹突狀細(xì)胞腫瘤的CD123。

36.Accuracy prompts are a replicable and generalizable approach for reducing the spread of misinformation.

準(zhǔn)確性提示是減少錯(cuò)誤信息傳播的一種可復(fù)制和可推廣的方法。

37.Heterozygous frameshift variants in HNRNPA2B1 cause early-onset oculopharyngeal muscular dystrophy.

HNRNPA2B1的雜合框架變異導(dǎo)致早發(fā)的眼咽肌肉萎縮癥。

38.A systems genomics approach to uncover patient-specific pathogenic pathways and proteins in ulcerative colitis.

用系統(tǒng)基因組學(xué)方法揭示潰瘍性結(jié)腸炎患者的特定致病途徑和蛋白質(zhì)。

39.Enhancement of anaerobic glycolysis – a role of PGC-1α4 in resistance exercise.

無(wú)氧糖酵解的增強(qiáng)--PGC-1α4在阻力運(yùn)動(dòng)中的作用。

40.Peptidoglycan biosynthesis is driven by lipid transfer along enzyme-substrate affinity gradients.

肽聚糖的生物合成是由沿酶-底物親和梯度的脂質(zhì)轉(zhuǎn)移驅(qū)動(dòng)的。

41.Three-dimensional structure determination of protein complexes using matrix-landing mass spectrometry.

利用矩陣著陸質(zhì)譜法確定蛋白質(zhì)復(fù)合物的三維結(jié)構(gòu)。

42.Leveraging omic features with F3UTER enables identification of unannotated 3’UTRs for synaptic genes.

利用F3UTER的omic特征，能夠識(shí)別突觸基因的未命名3'UTR。

43.The timing of differentiation and potency of CD8 effector function is set by RNA binding proteins.

分化的時(shí)間和CD8效應(yīng)功能的有效性是由RNA結(jié)合蛋白設(shè)定的。

44.Mutational meltdown of putative microbial altruists in Streptomyces coelicolor colonies.

Coelicolor鏈霉菌菌落中推測(cè)的微生物利他者的突變?nèi)诨?/p>

45.A cryptic pocket in Ebola VP35 allosterically controls RNA binding.

埃博拉病毒VP35中的一個(gè)隱性口袋異生控制了RNA的結(jié)合。

46.A distinctive ligand recognition mechanism by the human vasoactive intestinal polypeptide receptor 2.

人類血管活性腸多肽受體2的獨(dú)特配體識(shí)別機(jī)制。

47.ASCL1 activates neuronal stem cell-like lineage programming through remodeling of the chromatin landscape in prostate cancer.

ASCL1通過(guò)重塑前列腺癌的染色質(zhì)圖譜激活神經(jīng)元干細(xì)胞樣譜系編程。

48.L-tyrosine-bound ThiH structure reveals C–C bond break differences within radical SAM aromatic amino acid lyases.

L-酪氨酸結(jié)合的ThiH結(jié)構(gòu)揭示了自由基SAM芳香族氨基酸裂解酶內(nèi)部的C-C鍵斷裂差異。

49.Foldamers reveal and validate therapeutic targets associated with toxic α-synuclein self-assembly.

折疊體揭示并驗(yàn)證了與毒性α-突觸蛋白自組裝有關(guān)的治療目標(biāo)。

50.EWSR1-ATF1 dependent 3D connectivity regulates oncogenic and differentiation programs in Clear Cell Sarcoma.

EWSR1-ATF1依賴性三維連接調(diào)控透明細(xì)胞肉瘤的致癌和分化程序。

51.Covalent narlaprevir- and boceprevir-derived hybrid inhibitors of SARS-CoV-2 main protease.

SARS-CoV-2主要蛋白酶的共價(jià)narlaprevir和boceprevir衍生的混合抑制劑。

52.Safety and serum distribution of anti-SARS-CoV-2 monoclonal antibody MAD0004J08 after intramuscular injection.

肌肉注射后抗SARS-CoV-2單克隆抗體MAD0004J08的安全性和血清分布。

53.The initial charge separation step in oxygenic photosynthesis.

含氧光合作用中的初始電荷分離步驟。

54.T follicular helper and B cell crosstalk in tertiary lymphoid structures and cancer immunotherapy.

T濾泡輔助細(xì)胞和B細(xì)胞在三級(jí)淋巴結(jié)構(gòu)和癌癥免疫治療中的串?dāng)_。

55.Engineering artificial photosynthetic life-forms through endosymbiosis.

通過(guò)內(nèi)共生來(lái)設(shè)計(jì)人工光合作用的生命形式。

56.A periplasmic cinched protein is required for siderophore secretion and virulence of Mycobacterium tuberculosis.

結(jié)核分枝桿菌的苷脂分泌和毒力需要一種周身收縮的蛋白。

57.T cell receptor and IL-2 signaling strength control memory CD8+ T cell functional fitness via chromatin remodeling.

T細(xì)胞受體和IL-2信號(hào)強(qiáng)度通過(guò)染色質(zhì)重塑控制記憶型CD8+T細(xì)胞的功能適應(yīng)性。

58.Mesoscopic landscape of cortical functions revealed by through-skull wide-field optical imaging in marmoset monkeys.

通過(guò)顱內(nèi)寬視場(chǎng)光學(xué)成像揭示狨猴皮質(zhì)功能的中觀景觀。

59.Nanocrown electrodes for parallel and robust intracellular recording of cardiomyocytes.

用于心肌細(xì)胞平行和強(qiáng)大的細(xì)胞內(nèi)記錄的納米冠電極。

60.Cul3-KLHL20 E3 ubiquitin ligase plays a key role in the arms race between HIV-1 Nef and host SERINC5 restriction.

Cul3-KLHL20 E3泛素連接酶在HIV-1 Nef和宿主SERINC5限制的軍備競(jìng)賽中發(fā)揮關(guān)鍵作用。

61.Ebola virus VP35 hijacks the PKA-CREB1 pathway for replication and pathogenesis by AKIP1 association.

埃博拉病毒VP35通過(guò)與AKIP1聯(lián)合，劫持了PKA-CREB1通路進(jìn)行復(fù)制和致病。

62.Bloom helicase mediates formation of large single–stranded DNA loops during DNA end processing.

Bloom螺旋酶在DNA末端處理過(guò)程中介導(dǎo)了大型單鏈DNA環(huán)的形成。

63.Knockdown of GABAA alpha3 subunits on thalamic reticular neurons enhances deep sleep in mice.

丘腦網(wǎng)狀神經(jīng)元上GABAAα3亞基的敲除能增強(qiáng)小鼠的深度睡眠。

64.An osmium-peroxo complex for photoactive therapy of hypoxic tumors.

一種用于缺氧腫瘤光療的鋨-過(guò)氧化物復(fù)合物。

65.Spontaneous chiral symmetry breaking in a random driven chemical system.

隨機(jī)驅(qū)動(dòng)化學(xué)系統(tǒng)中自發(fā)的手性對(duì)稱性破壞。

66.Machine learning-coupled combinatorial mutagenesis enables resource-efficient engineering of CRISPR-Cas9 genome editor activities.

機(jī)器學(xué)習(xí)耦合的組合誘變使CRISPR-Cas9基因組編輯活動(dòng)的資源效率工程。

67.Deletion and tandem duplications of biosynthetic genes drive the diversity of triterpenoids in Aralia elata.

生物合成基因的刪除和串聯(lián)復(fù)制驅(qū)動(dòng)了Aralia elata的三萜類化合物的多樣性。

68.A dirigent family protein confers variation of Casparian strip thickness and salt tolerance in maize.

一個(gè)dirigent家族蛋白賦予了玉米的Casparian條帶厚度和耐鹽性的變化。

69.Transcription factors AP-2α and AP-2β regulate distinct segments of the distal nephron in the mammalian kidney.

轉(zhuǎn)錄因子AP-2α和AP-2β調(diào)節(jié)哺乳動(dòng)物腎臟遠(yuǎn)端腎小管的不同部分。

70.Ratiometric afterglow luminescent nanoplatform enables reliable quantification and molecular imaging.

比率余輝發(fā)光納米平臺(tái)實(shí)現(xiàn)了可靠的量化和分子成像。

71.Weight-bearing activity impairs nuclear membrane and genome integrity via YAP activation in plantar melanoma.

負(fù)重活動(dòng)通過(guò)YAP的激活損害了跖骨黑色素瘤的核膜和基因組完整性。

72.A structural exposé of noncanonical molecular reactivity within the protein tyrosine phosphatase WPD loop.

蛋白質(zhì)酪氨酸磷酸酶WPD環(huán)內(nèi)非經(jīng)典分子反應(yīng)性的結(jié)構(gòu)揭露。

73.Structure of ATP synthase under strain during catalysis.

催化過(guò)程中ATP合成酶受力的結(jié)構(gòu)。

74.Reduced chromatin accessibility correlates with resistance to Notch activation.

染色質(zhì)可及性的降低與對(duì)Notch激活的抵抗有關(guān)。

75.Cell-lineage controlled epigenetic regulation in glioblastoma stem cells determines functionally distinct subgroups and predicts patient survival.

膠質(zhì)母細(xì)胞瘤干細(xì)胞的細(xì)胞系控制的表觀遺傳調(diào)控決定了功能不同的亞群，并預(yù)測(cè)了患者的生存。

76.Shared and unique brain network features predict cognitive, personality, and mental health scores in the ABCD study.

共享和獨(dú)特的大腦網(wǎng)絡(luò)特征預(yù)測(cè)ABCD研究中的認(rèn)知、個(gè)性和心理健康分?jǐn)?shù)。

77.Genome-wide CRISPR screens identify GATA6 as a proviral host factor for SARS-CoV-2 via modulation of ACE2.

全基因組CRISPR篩選發(fā)現(xiàn)GATA6通過(guò)調(diào)節(jié)ACE2成為SARS-CoV-2的前病毒宿主因子。

78.A fungal extracellular effector inactivates plant polygalacturonase-inhibiting protein.

一種真菌的胞外效應(yīng)物使植物多聚半乳糖醛酸酶抑制蛋白失活。

79.Subthalamic nucleus stabilizes movements by reducing neural spike variability in monkey basal ganglia.

丘腦下部核團(tuán)通過(guò)減少猴子基底神經(jīng)節(jié)的神經(jīng)尖峰變異性來(lái)穩(wěn)定運(yùn)動(dòng)。

80.Machine learning-based global maps of ecological variables and the challenge of assessing them.

基于機(jī)器學(xué)習(xí)的生態(tài)變量全球地圖及評(píng)估挑戰(zhàn)

81.Chromatin profiling in human neurons reveals aberrant roles for histone acetylation and BET family proteins in schizophrenia.

人類神經(jīng)元的染色質(zhì)分析揭示了組蛋白乙酰化和BET家族蛋白在精神分裂癥中的反常作用。

82.Enabling reactive microscopy with MicroMator.

用MicroMator實(shí)現(xiàn)反應(yīng)性顯微鏡的研究。

83.Comparing COVID-19-related hospitalization rates among individuals with infection-induced and vaccine-induced immunity in Israel.

比較以色列具有感染誘導(dǎo)和疫苗誘導(dǎo)免疫力的個(gè)體中與COVID-19相關(guān)的住院率。

84.Genetic analysis of over half a million people characterises C-reactive protein loci.

對(duì)50多萬(wàn)人的遺傳分析表明了C反應(yīng)蛋白位點(diǎn)的特點(diǎn)。

85.Pathogenic BRCA1 variants disrupt PLK1-regulation of mitotic spindle orientation.

致病的BRCA1變體破壞了PLK1對(duì)有絲分裂紡錘體定向的調(diào)節(jié)。

86.Mechanism of sensitivity modulation in the calcium-sensing receptor via electrostatic tuning.

鈣感應(yīng)受體中通過(guò)靜電調(diào)諧的靈敏度調(diào)節(jié)機(jī)制。

87.A targetable CoQ-FSP1 axis drives ferroptosis- and radiation-resistance in KEAP1 inactive lung cancers.

可靶向的CoQ-FSP1軸驅(qū)動(dòng)KEAP1不活躍的肺癌的鐵中毒和抗輻射性。

88.CinA mediates multidrug tolerance in Mycobacterium tuberculosis.

CinA介導(dǎo)了結(jié)核分枝桿菌的多藥耐受。

89.Supraphysiological activation of TAK1 promotes skeletal muscle growth and mitigates neurogenic atrophy.

TAK1的超生理激活促進(jìn)骨骼肌生長(zhǎng)并減輕神經(jīng)源性萎縮。

90.ZNF117 regulates glioblastoma stem cell differentiation towards oligodendroglial lineage.

ZNF117調(diào)控膠質(zhì)母細(xì)胞瘤干細(xì)胞向少突膠質(zhì)細(xì)胞系分化。

91.Generic self-stabilization mechanism for biomolecular adhesions under load.

負(fù)載下的生物分子粘附的通用自穩(wěn)定機(jī)制。

92.Bottlenecks and opportunities for synthetic biology biosafety standards.

合成生物學(xué)生物安全標(biāo)準(zhǔn)的瓶頸和機(jī)遇。

93.Single-cell transcriptomics identifies Mcl-1 as a target for senolytic therapy in cancer.

單細(xì)胞轉(zhuǎn)錄組學(xué)發(fā)現(xiàn)Mcl-1是癌癥中衰老治療的目標(biāo)。

94.PD-L1 signaling selectively regulates T cell lymphatic transendothelial migration.

PD-L1信號(hào)傳導(dǎo)選擇性地調(diào)節(jié)T細(xì)胞淋巴跨內(nèi)皮遷移.

95.Redesigning regulatory components of quorum-sensing system for diverse metabolic control.

重新設(shè)計(jì)法定人數(shù)感應(yīng)系統(tǒng)的調(diào)節(jié)組件以實(shí)現(xiàn)多樣化的代謝控制。

96.KMT5A-methylated SNIP1 promotes triple-negative breast cancer metastasis by activating YAP signaling.

KMT5A甲基化的SNIP1通過(guò)激活YAP信號(hào)傳導(dǎo)促進(jìn)三陰性乳腺癌的轉(zhuǎn)移。

97.Emergence of novel cephalopod gene regulation and expression through large-scale genome reorganization.

通過(guò)大規(guī)?；蚪M重組出現(xiàn)的新型頭足類基因調(diào)控和表達(dá)。

98.Integrated profiling of human pancreatic cancer organoids reveals chromatin accessibility features associated with drug sensitivity.

人類胰腺癌器官的綜合分析揭示了與藥物敏感性相關(guān)的染色質(zhì)可及性特征。

99.Snf7 spirals sense and alter membrane curvature.

Snf7螺旋體感知并改變膜曲率。

100.Niche expansion and adaptive divergence in the global radiation of crows and ravens.

烏鴉和烏鴉的全球輻射中的利基擴(kuò)展和適應(yīng)性分化。

101.Golgi apparatus-targeted aggregation-induced emission luminogens for effective cancer photodynamic therapy.

用于有效癌癥光動(dòng)力治療的高爾基體靶向聚集誘導(dǎo)發(fā)射發(fā)光體。

102.App-based COVID-19 syndromic surveillance and prediction of hospital admissions in COVID Symptom Study Sweden.

基于應(yīng)用程序的COVID-19綜合癥監(jiān)測(cè)和預(yù)測(cè)瑞典COVID癥狀研究中的入院情況。

103.USP22 regulates lipidome accumulation by stabilizing PPARγ in hepatocellular carcinoma.

USP22通過(guò)穩(wěn)定肝細(xì)胞癌的PPARγ來(lái)調(diào)節(jié)脂質(zhì)體的積累。

104.AI-enabled, implantable, multichannel wireless telemetry for photodynamic therapy.

用于光動(dòng)力療法的AI-enabled、植入式、多通道無(wú)線遙測(cè)技術(shù)。

105.CMYA5 establishes cardiac dyad architecture and positioning.

CMYA5建立了心臟dyad架構(gòu)和定位。

106.Metabolic plasticity can amplify ecosystem responses to global warming.

代謝的可塑性可以放大生態(tài)系統(tǒng)對(duì)全球變暖的反應(yīng)。

107.TRMT6/61A-dependent base methylation of tRNA-derived fragments regulates gene-silencing activity and the unfolded protein response in bladder cancer.

TRMT6/61A依賴的tRNA衍生片段的堿基甲基化調(diào)節(jié)膀胱癌的基因沉默活性和未折疊蛋白反應(yīng)。

108.RNA polymerase II pausing factor NELF in CD8+ T cells promotes antitumor immunity.

CD8+T細(xì)胞中的RNA聚合酶II暫停因子NELF促進(jìn)抗腫瘤免疫力。

109.Vasa nucleates asymmetric translation along the mitotic spindle during unequal cell divisions.

在不平等的細(xì)胞分裂過(guò)程中，Vasa核沿有絲分裂紡錘體進(jìn)行不對(duì)稱的翻譯。

110.Tension can directly suppress Aurora B kinase-triggered release of kinetochore-microtubule attachments.

張力可直接抑制Aurora B激酶觸發(fā)的激振子-微管附著物的釋放。

111.High-throughput production of functional prototissues capable of producing NO for vasodilation.

高通量生產(chǎn)能夠產(chǎn)生NO用于血管擴(kuò)張的功能性原型組織。

112.Targeting brain lesions of non-small cell lung cancer by enhancing CCL2-mediated CAR-T cell migration.

通過(guò)增強(qiáng)CCL2介導(dǎo)的CAR-T細(xì)胞遷移來(lái)鎖定非小細(xì)胞肺癌的腦部病灶。

113.Single cell transcriptomic analysis reveals cellular diversity of murine esophageal epithelium.

單細(xì)胞轉(zhuǎn)錄組分析揭示了小鼠食道上皮細(xì)胞的多樣性。

114.Lateral gain is impaired in macular degeneration and can be targeted to restore vision in mice.

側(cè)面增益在黃斑變性中受損，可作為小鼠恢復(fù)視力的目標(biāo)。

115.Genomic and metabolic adaptations of biofilms to ecological windows of opportunity in glacier-fed streams.

生物膜對(duì)冰川流的生態(tài)機(jī)會(huì)窗口的基因組和代謝適應(yīng)。

116.Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183.

抗瘧藥泛酸MMV693183的臨床前特征和目標(biāo)驗(yàn)證。

117.Stearoyl-CoA Desaturase inhibition reverses immune, synaptic and cognitive impairments in an Alzheimer’s disease mouse model.

抑制硬脂酰-CoA去飽和酶可逆轉(zhuǎn)阿爾茨海默病小鼠模型的免疫、突觸和認(rèn)知損傷。

118.Differential effects of macrophage subtypes on SARS-CoV-2 infection in a human pluripotent stem cell-derived model.

巨噬細(xì)胞亞型對(duì)人類多能干細(xì)胞衍生模型中SARS-CoV-2感染的不同影響。

119.A loss-of-adhesion CRISPR-Cas9 screening platform to identify cell adhesion-regulatory proteins and signaling pathways.

識(shí)別細(xì)胞粘附調(diào)節(jié)蛋白和信號(hào)通路的失粘性CRISPR-Cas9篩選平臺(tái)。

120.Spontaneous variability in gamma dynamics described by a damped harmonic oscillator driven by noise.

由噪聲驅(qū)動(dòng)的阻尼諧波振蕩器所描述的伽馬動(dòng)力學(xué)的自發(fā)變化。

121.Normalizing and denoising protein expression data from droplet-based single cell profiling.

對(duì)基于液滴的單細(xì)胞分析的蛋白質(zhì)表達(dá)數(shù)據(jù)進(jìn)行標(biāo)準(zhǔn)化和去噪處理。

122.Global ubiquitinome profiling identifies NEDD4 as a regulator of Profilin 1 and actin remodelling in neural crest cells.

全球泛素組分析確定NEDD4是神經(jīng)嵴細(xì)胞中Profilin 1和肌動(dòng)蛋白重塑的調(diào)節(jié)器。

123.Human serum triggers antibiotic tolerance in Staphylococcus aureus.

人類血清引發(fā)了金黃色葡萄球菌的抗生素耐受性。

124.Development of NanoLuc-targeting protein degraders and a universal reporter system to benchmark tag-targeted degradation platforms.

開發(fā)NanoLuc靶向蛋白降解劑和通用報(bào)告系統(tǒng)，以確定標(biāo)簽靶向降解平臺(tái)的基準(zhǔn)。

125.USP25 promotes pathological HIF-1-driven metabolic reprogramming and is a potential therapeutic target in pancreatic cancer.

USP25促進(jìn)病理性HIF-1驅(qū)動(dòng)的代謝重編程，是胰腺癌的潛在治療目標(biāo)。

126.Single cell analyses identify a highly regenerative and homogenous human CD34+?hematopoietic stem cell population.

單細(xì)胞分析確定了一個(gè)高度再生和同質(zhì)的人類CD34+造血干細(xì)胞群。

127.Multilayered regulations of alternative splicing, NMD, and protein stability control temporal induction and tissue-specific expression of TRIM46 during axon formation.

替代剪接、NMD和蛋白質(zhì)穩(wěn)定性的多層次調(diào)節(jié)控制了TRIM46在軸突形成過(guò)程中的時(shí)間誘導(dǎo)和組織特異性表達(dá)。

128.Local and substrate-specific S-palmitoylation determines subcellular localization of Gαo.

局部和底物特異性的S-棕櫚酰化決定了Gαo的亞細(xì)胞定位。

129.A hierarchy of biomolecular proportional-integral-derivative feedback controllers for robust perfect adaptation and dynamic performance.

生物分子比例-積分-衍生反饋控制器的層次結(jié)構(gòu)，用于強(qiáng)大的完美適應(yīng)和動(dòng)態(tài)性能。

130.Distinct resistance mechanisms arise to allosteric vs. ATP-competitive AKT inhibitors.

對(duì)異源性與ATP競(jìng)爭(zhēng)性AKT抑制劑產(chǎn)生不同的抗性機(jī)制。

131.High-quality genome and methylomes illustrate features underlying evolutionary success of oaks.

高質(zhì)量的基因組和甲基組說(shuō)明了橡樹進(jìn)化成功的基本特征。

132.Cooperative interaction between ERα and the EMT-inducer ZEB1 reprograms breast cancer cells for bone metastasis.

ERα和EMT誘導(dǎo)劑ZEB1之間的合作互動(dòng)為乳腺癌細(xì)胞的骨轉(zhuǎn)移重新編程。

133.An anti-influenza A virus microbial metabolite acts by degrading viral endonuclease PA.

一種抗甲型流感病毒的微生物代謝物通過(guò)降解病毒內(nèi)切酶PA發(fā)揮作用。

134.Genomic distances reveal relationships of wild and cultivated beets.

基因組距離揭示野生和栽培甜菜的關(guān)系。

135.TNF is a potential therapeutic target to suppress prostatic inflammation and hyperplasia in autoimmune disease.

TNF是抑制自身免疫性疾病中前列腺炎癥和增生的潛在治療目標(biāo)。

136.Accelerated biological aging in COVID-19 patients.

COVID-19患者的生物衰老加速。

137.Pyridine nucleotide redox potential in coronary smooth muscle couples myocardial blood flow to cardiac metabolism.

冠狀動(dòng)脈平滑肌中的吡啶核苷酸氧化還原電位將心肌血流與心臟代謝聯(lián)系起來(lái)。

138.Astroblastomas exhibit radial glia stem cell lineages and differential expression of imprinted and X-inactivation escape genes.

星形細(xì)胞瘤表現(xiàn)出放射狀膠質(zhì)干細(xì)胞譜系以及印記和X-失活逃逸基因的不同表達(dá)。

139.ESR1 mutant breast cancers show elevated basal cytokeratins and immune activation.

ESR1突變的乳腺癌顯示出基底細(xì)胞角蛋白的升高和免疫激活。

140.The neural coding framework for learning generative models.

學(xué)習(xí)生成模型的神經(jīng)編碼框架。

141.Information normally considered task-irrelevant drives decision-making and affects premotor circuit recruitment.

通常被認(rèn)為與任務(wù)無(wú)關(guān)的信息驅(qū)動(dòng)決策并影響運(yùn)動(dòng)前電路的招募。

142.Low complexity RGG-motif sequence is required for Processing body (P-body) disassembly.

處理體（P-body）的分解需要低復(fù)雜度的RGG-motif序列。

143.Intestinal fibroblastic reticular cell niches control innate lymphoid cell homeostasis and function.

腸道纖維網(wǎng)狀細(xì)胞龕控制先天淋巴細(xì)胞的平衡和功能。

144.Bipartite network models to design combination therapies in acute myeloid leukaemia.

設(shè)計(jì)急性骨髓性白血病聯(lián)合療法的雙元網(wǎng)絡(luò)模型。

145.Magic angle spinning NMR structure of human cofilin-2 assembled on actin filaments reveals isoform-specific conformation and binding mode.

裝配在肌動(dòng)蛋白絲上的人類cofilin-2的魔角旋轉(zhuǎn)核磁共振結(jié)構(gòu)揭示了同種形式的特定構(gòu)象和結(jié)合模式。

146.AKT mutant allele-specific activation dictates pharmacologic sensitivities.

AKT突變體等位基因的激活決定了藥理學(xué)的敏感性。

147.Loss of vascular endothelial notch signaling promotes spontaneous formation of tertiary lymphoid structures.

血管內(nèi)皮缺口信號(hào)的喪失促進(jìn)三級(jí)淋巴結(jié)構(gòu)的自發(fā)形成。

148.Cavβ1 regulates T cell expansion and apoptosis independently of voltage-gated Ca2+ channel function.

Cavβ1獨(dú)立于電壓門控Ca2+通道功能調(diào)節(jié)T細(xì)胞擴(kuò)張和凋亡。

149.A proteogenomic analysis of clear cell renal cell carcinoma in a C population.

C人群中透明細(xì)胞腎細(xì)胞癌的蛋白質(zhì)基因組學(xué)分析。

150.Structural insights into the peptide selectivity and activation of human neuromedin U receptors.

肽的選擇性和人類神經(jīng)素U受體的激活的結(jié)構(gòu)性見解。

151.Genomic and transcriptomic analysis of a library of small cell lung cancer patient-derived xenografts.

小細(xì)胞肺癌患者衍生的異種移植庫(kù)的基因組和轉(zhuǎn)錄組分析。

152.A natural allele of OsMS1 responds to temperature changes and confers thermosensitive genic male sterility.

OsMS1的一個(gè)天然等位基因?qū)囟茸兓蟹磻?yīng)，并賦予熱敏基因雄性不育。

153.Inhibition of the succinyl dehydrogenase complex in acute myeloid leukemia leads to a lactate-fuelled respiratory metabolic vulnerability.

抑制急性骨髓性白血病中的琥珀酰脫氫酶復(fù)合物導(dǎo)致乳酸鹽驅(qū)動(dòng)的呼吸道代謝脆弱。

154.DENR controls JAK2 translation to induce PD-L1 expression for tumor immune evasion.

DENR控制JAK2翻譯，誘導(dǎo)PD-L1表達(dá)，用于腫瘤免疫逃避。

155.Regulated interaction of ID2 with the anaphase-promoting complex links progression through mitosis with reactivation of cell-type-specific transcription.

ID2與無(wú)性繁殖復(fù)合物的調(diào)節(jié)性相互作用將有絲分裂的進(jìn)展與細(xì)胞類型特異性轉(zhuǎn)錄的重新激活聯(lián)系起來(lái)。

156.Distinct and additive effects of calorie restriction and rapamycin in aging skeletal muscle.

卡路里限制和雷帕霉素在老化骨骼肌中的獨(dú)特和相加效應(yīng)。

157.Boron encapsulated in a liposome can be used for combinational neutron capture therapy.

包裹在脂質(zhì)體中的硼可用于組合式中子捕獲療法。

158.CO2 signaling mediates neurovascular coupling in the cerebral cortex.

CO2信號(hào)介導(dǎo)大腦皮層的神經(jīng)血管偶聯(lián)。

159.Chemotherapy-induced COX-2 upregulation by cancer cells defines their inflammatory properties and limits the efficacy of chemoimmunotherapy combinations.

化療誘導(dǎo)的癌細(xì)胞COX-2上調(diào)確定了其炎癥特性，并限制了化療免疫療法組合的療效。

160.A leukemia-protective germline variant mediates chromatin module formation via transcription factor nucleation.

一種白血病保護(hù)性種系變體通過(guò)轉(zhuǎn)錄因子成核介導(dǎo)染色質(zhì)模塊形成。

161.Analysis of sub-kilobase chromatin topology reveals nano-scale regulatory interactions with variable dependence on cohesin and CTCF.

對(duì)亞千堿基染色質(zhì)拓?fù)浣Y(jié)構(gòu)的分析揭示了納米級(jí)的調(diào)控相互作用，對(duì)聚合酶和CTCF的依賴程度不同。

162.Targeting TCTP sensitizes tumor to T cell-mediated therapy by reversing immune-refractory phenotypes.

靶向TCTP通過(guò)逆轉(zhuǎn)免疫難治的表型使腫瘤對(duì)T細(xì)胞介導(dǎo)的治療敏感。

163.Heterogeneity of neuroendocrine transcriptional states in metastatic small cell lung cancers and patient-derived models.

轉(zhuǎn)移性小細(xì)胞肺癌和患者衍生模型中神經(jīng)內(nèi)分泌轉(zhuǎn)錄狀態(tài)的異質(zhì)性。

164.Bird populations most exposed to climate change are less sensitive to climatic variation.

最受氣候變化影響的鳥類種群對(duì)氣候變異的敏感性較低。

165.Insulin action and resistance are dependent on a GSK3β-FBXW7-ERRα transcriptional axis.

胰島素的作用和抵抗依賴于GSK3β-FBXW7-ERRα的轉(zhuǎn)錄軸。

166.Microridge-like structures anchor motile cilia.

微脊?fàn)罱Y(jié)構(gòu)固定了運(yùn)動(dòng)的纖毛。

167.Honeybee gut Lactobacillus modulates host learning and memory behaviors via regulating tryptophan metabolism.

蜜蜂腸道乳酸菌通過(guò)調(diào)節(jié)色氨酸代謝調(diào)節(jié)宿主學(xué)習(xí)和記憶行為。

168.Structure, gating, and pharmacology of human CAV3.3 channel.

人類CAV3.3通道的結(jié)構(gòu)、門控和藥理學(xué)。

169.A POLD3/BLM dependent pathway handles DSBs in transcribed chromatin upon excessive RNA:DNA hybrid accumulation.

POLD3/BLM依賴性途徑處理RNA：DNA雜交積累過(guò)多時(shí)轉(zhuǎn)錄染色質(zhì)中的DSBs。

170.An evolutionarily conserved stop codon enrichment at the 5′ ends of mammalian piRNAs.

哺乳動(dòng)物piRNA的5′端有一個(gè)進(jìn)化保守的終止密碼子富集。

171.Gut microbiota-bile acid crosstalk contributes to the rebound weight gain after calorie restriction in mice.

腸道微生物群-膽汁酸串聯(lián)有助于小鼠熱量限制后體重的反彈性增加。

172.Secondary structure RNA elements control the cleavage activity of DICER.

二級(jí)結(jié)構(gòu)RNA元素控制DICER的裂解活性。

173.Connecting high-resolution 3D chromatin organization with epigenomics.

高分辨率三維染色質(zhì)組織與表觀基因組學(xué)的聯(lián)系。

174.Bioorthogonal in situ assembly of nanomedicines as drug depots for extracellular drug delivery.

生物正交原位組裝的納米藥物作為細(xì)胞外給藥的藥物庫(kù)。

175.An analysis of neuroscience and psychiatry papers published from 2009 and 2019 outlines opportunities for increasing discovery of sex differences.

對(duì)2009年至2019年發(fā)表的神經(jīng)科學(xué)和精神病學(xué)論文的分析，概述了增加發(fā)現(xiàn)性別差異的機(jī)會(huì)。

176.A single-cell nanocoating of probiotics for enhanced amelioration of antibiotic-associated diarrhea.

用于增強(qiáng)改善抗生素相關(guān)腹瀉的益生菌的單細(xì)胞納米涂層。

177.Generation of human islet cell type-specific identity genesets.

人類胰島細(xì)胞類型特異性身份基因組的產(chǎn)生。

178.Endothelial progenitor cells stimulate neonatal lung angiogenesis through FOXF1-mediated activation of BMP9/ACVRL1 signaling.

內(nèi)皮祖細(xì)胞通過(guò)FOXF1介導(dǎo)的BMP9/ACVRL1信號(hào)的激活刺激新生兒肺部血管生成。

179.Communication-efficient federated learning via knowledge distillation.

通過(guò)知識(shí)提煉實(shí)現(xiàn)溝通效率的聯(lián)合學(xué)習(xí)。

180.Local structure-function relationships in human brain networks across the lifespan.

人類大腦網(wǎng)絡(luò)在整個(gè)生命周期中的局部結(jié)構(gòu)-功能關(guān)系。

181.Membrane marker selection for segmenting single cell spatial proteomics data.

用于分割單細(xì)胞空間蛋白質(zhì)組學(xué)數(shù)據(jù)的膜標(biāo)志物選擇。

182.Chromosome evolution and the genetic basis of agronomically important traits in greater yam.

大山藥的染色體進(jìn)化和重要農(nóng)藝性狀的遺傳基礎(chǔ)。

183.Hidden information on protein function in censuses of proteome foldedness.

蛋白質(zhì)組折疊度普查中隱藏的蛋白質(zhì)功能信息。

184.Interactive single-cell data analysis using Cellar.

使用Cellar的交互式單細(xì)胞數(shù)據(jù)分析.

185.A pair of non-Mendelian genes at the Ga2 locus confer unilateral cross-incompatibility in maize.

玉米Ga2基因座上的一對(duì)非孟德爾基因賦予玉米單側(cè)交叉相容性。

186.Light triggered nanoscale biolistics for efficient intracellular delivery of functional macromolecules in mammalian cells.

哺乳動(dòng)物細(xì)胞中功能性大分子的高效細(xì)胞內(nèi)傳遞的光觸發(fā)納米生物技術(shù)。

187.Proteolysis of adaptor protein Mmr1 during budding is necessary for mitochondrial homeostasis in Saccharomyces cerevisiae.

發(fā)芽過(guò)程中適應(yīng)蛋白Mmr1的蛋白分解對(duì)釀酒酵母的線粒體穩(wěn)態(tài)是必要的。

188.Differences in RNA polymerase II complexes and their interactions with surrounding chromatin on human and cytomegalovirus genomes.

人類和巨細(xì)胞病毒基因組上的RNA聚合酶II復(fù)合體及其與周圍染色質(zhì)的相互作用的差異。

189.CDP-ribitol prodrug treatment ameliorates ISPD-deficient muscular dystrophy mouse model.

CDP-核糖醇原藥治療改善ISPD缺陷型肌肉萎縮癥小鼠模型。

190.Microvascular stabilization via blood-brain barrier regulation prevents seizure activity.

通過(guò)血腦屏障調(diào)節(jié)微血管穩(wěn)定可防止癲癇活動(dòng)。

191.Adaptive responses of marine diatoms to zinc scarcity and ecological implications.

海洋硅藻對(duì)鋅匱乏的適應(yīng)性反應(yīng)及生態(tài)學(xué)意義。

192.The nuclear receptor ERR cooperates with the cardiogenic factor GATA4 to orchestrate cardiomyocyte maturation.

核受體ERR與致心因子GATA4合作，協(xié)調(diào)心肌細(xì)胞的成熟。

193.Data-driven learning how oncogenic gene expression locally alters heterocellular networks.

數(shù)據(jù)驅(qū)動(dòng)的學(xué)習(xí)：致癌基因表達(dá)如何局部改變異質(zhì)細(xì)胞網(wǎng)絡(luò)。

194.Genomic evidence for homoploid hybrid speciation between ancestors of two different genera.

兩個(gè)不同屬的祖先之間的同倍體雜交物種的基因組證據(jù)。

195.Structural basis for the assembly and quinone transport mechanisms of the dimeric photosynthetic RC–LH1 supercomplex.

二聚體光合作用RC-LH1超級(jí)復(fù)合體的組裝和醌運(yùn)輸機(jī)制的結(jié)構(gòu)基礎(chǔ)。

196.PD-L1 and ICOSL discriminate human Secretory and Helper dendritic cells in cancer, allergy and autoimmunity.

PD-L1和ICOSL在癌癥、過(guò)敏和自身免疫中對(duì)人類分泌型和幫助型樹突狀細(xì)胞的鑒別。

197.Protection following BNT162b2 booster in adolescents substantially exceeds that of a fresh 2-dose vaccine.

青少年BNT162b2強(qiáng)化后的保護(hù)作用大大超過(guò)新鮮2劑疫苗的保護(hù)作用。

198.Presenilin 2 N141I mutation induces hyperactive immune response through the epigenetic repression of REV-ERBα.

Presenilin 2 N141I突變通過(guò)表觀遺傳學(xué)抑制REV-ERBα誘發(fā)高活性免疫反應(yīng)。

199.Nuclear translocation of p85β promotes tumorigenesis of PIK3CA helical domain mutant cancer.

p85β的核轉(zhuǎn)位促進(jìn)PIK3CA螺旋結(jié)構(gòu)域突變癌的腫瘤發(fā)生。

200.Sympathetic axonal sprouting induces changes in macrophage populations and protects against pancreatic cancer.

交感神經(jīng)軸突萌發(fā)誘導(dǎo)巨噬細(xì)胞種群變化并保護(hù)胰腺癌。

201.CHD7 regulates bone-fat balance by suppressing PPAR-γ signaling.

CHD7通過(guò)抑制PPAR-γ信號(hào)調(diào)節(jié)骨脂肪平衡。

202.Using deep learning to predict abdominal age from liver and pancreas magnetic resonance images.

使用深度學(xué)習(xí)從肝臟和胰腺磁共振圖像預(yù)測(cè)腹部年齡。

203.Modeling the disruption of respiratory disease clinical trials by non-pharmaceutical COVID-19 interventions.

非藥物COVID-19干預(yù)措施對(duì)呼吸系統(tǒng)疾病臨床試驗(yàn)的干擾建模。

204.Anopheles mosquitoes reveal new principles of 3D genome organization in insects.

按蚊揭示了昆蟲三維基因組組織的新原則。

205.Human pancreatic microenvironment promotes β-cell differentiation via non-canonical WNT5A/JNK and BMP signaling.

人類胰腺微環(huán)境通過(guò)非經(jīng)典的WNT5A/JNK和BMP信號(hào)促進(jìn)β細(xì)胞分化。

206.Inducible and reversible RNA N6-methyladenosine editing.

誘導(dǎo)性和可逆性RNA N6-甲基腺苷編輯。

207.Long-term in vivo imaging of mouse spinal cord through an optically cleared intervertebral window.

通過(guò)光學(xué)清除的椎間孔窗對(duì)小鼠脊髓進(jìn)行長(zhǎng)期的體內(nèi)成像。

208.ComFC mediates transport and handling of single-stranded DNA during natural transformation.

ComFC介導(dǎo)了自然轉(zhuǎn)化過(guò)程中單鏈DNA的運(yùn)輸和處理。

209.Population-scale long-read sequencing uncovers transposable elements associated with gene expression variation and adaptive signatures in Drosophila.

群體規(guī)模的長(zhǎng)讀測(cè)序發(fā)現(xiàn)了與果蠅基因表達(dá)變化和適應(yīng)性特征相關(guān)的可轉(zhuǎn)座元素。

210.A machine learning algorithm with subclonal sensitivity reveals widespread pan-cancer human leukocyte antigen loss of heterozygosity.

具有亞克隆敏感性的機(jī)器學(xué)習(xí)算法揭示了廣泛的泛癌癥人類白細(xì)胞抗原雜合度的喪失。

211.The crystal structure of iC3b-CR3 αI reveals a modular recognition of the main opsonin iC3b by the CR3 integrin receptor.

iC3b-CR3?αI的晶體結(jié)構(gòu)揭示了CR3整合素受體對(duì)主要造血干細(xì)胞iC3b的模塊化識(shí)別。

212.Persistent COVID-19 symptoms in a community study of 606,434 people in England.

英國(guó)一項(xiàng)對(duì)606,434人的社區(qū)研究中的持續(xù)COVID-19癥狀。

213.Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy.

小膠質(zhì)細(xì)胞NF-κB驅(qū)動(dòng)tauopathy小鼠模型中tau的擴(kuò)散和毒性。

214.Distinct molecular and immune hallmarks of inflammatory arthritis induced by immune checkpoint inhibitors for cancer therapy.

用于癌癥治療的免疫檢查點(diǎn)抑制劑誘發(fā)的炎癥性關(guān)節(jié)炎的獨(dú)特分子和免疫特征。

215.Using high-resolution contact networks to evaluate SARS-CoV-2 transmission and control in large-scale multi-day events.

使用高分辨率接觸網(wǎng)絡(luò)評(píng)估SARS-CoV-2在大規(guī)模多日活動(dòng)中的傳播和控制。

216.SWI/SNF and the histone chaperone Rtt106 drive expression of the Pleiotropic Drug Resistance network genes.

SWI/SNF和組蛋白伴侶Rtt106驅(qū)動(dòng)多種抗藥性網(wǎng)絡(luò)基因的表達(dá)。

217.Deforestation-induced climate change reduces carbon storage in remaining tropical forests.

毀林引起的氣候變化減少了剩余熱帶森林的碳儲(chǔ)存。

218.Trade-off between tree planting and wetland conservation in China.

中國(guó)植樹和濕地保護(hù)之間的權(quán)衡。

219.Multidimensional chromatin profiling of zebrafish pancreas to uncover and investigate disease-relevant enhancers.

斑馬魚胰腺的多維染色質(zhì)譜分析，發(fā)現(xiàn)并研究與疾病相關(guān)的增強(qiáng)子。

220.Ubiquitin-like protein 3 (UBL3) is required for MARCH ubiquitination of major histocompatibility complex class II and CD86.

泛素樣蛋白?3 (UBL3)?是主要組織相容性復(fù)合體?II?類和?CD86?的?MARCH?泛素化所必需的。

221.Insights into the inhibition of type I-F CRISPR-Cas system by a multifunctional anti-CRISPR protein AcrIF24.

對(duì)多功能抗CRISPR蛋白AcrIF24抑制I-F型CRISPR-Cas系統(tǒng)的深入研究。

222.Transient viral exposure drives functionally-coordinated humoral immune responses in HIV-1 post-treatment controllers.

暫時(shí)性病毒暴露驅(qū)動(dòng)HIV-1治療后控制者的功能協(xié)調(diào)的體液免疫反應(yīng)。

223.Single-cell RNA sequencing coupled to TCR profiling of large granular lymphocyte leukemia T cells.

單細(xì)胞RNA測(cè)序與大顆粒淋巴細(xì)胞白血病T細(xì)胞的TCR分析相結(jié)合。

224.Impact of horizontal gene transfer on emergence and stability of cooperative virulence in Salmonella Typhimurium.

水平基因轉(zhuǎn)移對(duì)鼠疫沙門氏菌合作毒力的出現(xiàn)和穩(wěn)定性的影響。

225.Reprogrammed tracrRNAs enable repurposing of RNAs as crRNAs and sequence-specific RNA biosensors.

重新編程的tracrRNAs使RNA被重新利用為crRNAs和序列特定的RNA生物傳感器。

226.Single-cell characterization of leukemic and non-leukemic immune repertoires in CD8+ T-cell large granular lymphocytic leukemia.

CD8+T細(xì)胞大顆粒淋巴細(xì)胞白血病中白血病和非白血病免疫復(fù)合物的單細(xì)胞特征。

227.Neoantigen-specific CD8 T cell responses in the peripheral blood following PD-L1 blockade might predict therapy outcome in metastatic urothelial carcinoma.

PD-L1阻斷后外周血中的新抗原特異性CD8 T細(xì)胞反應(yīng)可能預(yù)測(cè)轉(zhuǎn)移性尿路上皮癌的治療結(jié)果。

228.Designing highly multiplex PCR primer sets with Simulated Annealing Design using Dimer Likelihood Estimation (SADDLE).

使用二聚體似然估計(jì)(SADDLE)?通過(guò)模擬退火設(shè)計(jì)設(shè)計(jì)高度多重?PCR?引物組。

229.Carbonized paramagnetic complexes of Mn (II) as contrast agents for precise magnetic resonance imaging of sub-millimeter-sized orthotopic tumors.

Mn (II)的碳化順磁性復(fù)合物作為造影劑用于亞毫米級(jí)正位腫瘤的精確磁共振成像。

230.Electrocorticographic evidence of a common neurocognitive sequence for mentalizing about the self and others.

皮質(zhì)電圖證明了對(duì)自我和他人進(jìn)行心理暗示的共同神經(jīng)認(rèn)知序列。

231.Mechanical control of innate immune responses against viral infection revealed in a human lung alveolus chip.

在人類肺泡芯片中發(fā)現(xiàn)的針對(duì)病毒感染的先天免疫反應(yīng)的機(jī)械控制。

232.Congruent evolutionary responses of European steppe biota to late Quaternary climate change.

歐洲草原生物群對(duì)第四紀(jì)晚期氣候變化的一致的進(jìn)化反應(yīng)。

233.Learning meaningful representations of protein sequences.

學(xué)習(xí)有意義的蛋白質(zhì)序列表征.

234.Functional control of a 0.5 MDa TET aminopeptidase by a flexible loop revealed by MAS NMR.

通過(guò)MAS NMR揭示靈活環(huán)路對(duì)0.5 MDa TET氨基肽酶的功能控制。

235.Ubiquitin ligase STUB1 destabilizes IFNγ-receptor complex to suppress tumor IFNγ signaling.

泛素連接酶STUB1破壞IFNγ受體復(fù)合物的穩(wěn)定性以抑制腫瘤IFNγ信號(hào)傳導(dǎo)。

236.Emergence and phenotypic characterization of the global SARS-CoV-2 C.1.2 lineage.

全球SARS-CoV-2 C.1.2系的出現(xiàn)和表型特征。

237.In vivo imaging of invasive aspergillosis with 18F-fluorodeoxysorbitol positron emission tomography.

18F-氟脫氧山梨醇正電子發(fā)射斷層掃描對(duì)侵襲性曲霉病的體內(nèi)成像。

238.Angular and linear speed cells in the parahippocampal circuits.

海馬旁回路中的角度和線性速度細(xì)胞。

239.Glyco-Decipher enables glycan database-independent peptide matching and in-depth characterization of site-specific N-glycosylation.

Glyco-Decipher使糖數(shù)據(jù)庫(kù)獨(dú)立于肽的匹配和特定位點(diǎn)N-糖基化的深入特征。

240.Collateral sensitivity to pleuromutilins in vancomycin-resistant Enterococcus faecium.

萬(wàn)古霉素耐藥腸球菌對(duì)胸腺素的附帶敏感性。

241.Reshuffling of the ancestral core-eudicot genome shaped chromatin topology and epigenetic modification in Panax.

祖先核心植物基因組的重新排列塑造了三七的染色質(zhì)拓?fù)浣Y(jié)構(gòu)和表觀遺傳修飾。

242.Development of optimized drug-like small molecule inhibitors of the SARS-CoV-2 3CL protease for treatment of COVID-19.

用于治療COVID-19的SARS-CoV-2 3CL蛋白酶的優(yōu)化藥樣小分子抑制劑的開發(fā)。

243.Asymmetric structure of the native Rhodobacter sphaeroides dimeric LH1–RC complex.

原生的紅豆菌二聚體LH1-RC復(fù)合物的不對(duì)稱結(jié)構(gòu)。

244.Enhancing biofuels production by engineering the actin cytoskeleton in Saccharomyces cerevisiae.

通過(guò)在釀酒酵母中設(shè)計(jì)肌動(dòng)蛋白細(xì)胞骨架來(lái)加強(qiáng)生物燃料的生產(chǎn)。

245.MiDAS 4: A global catalogue of full-length 16S rRNA gene sequences and taxonomy for studies of bacterial communities in wastewater treatment plants.

MiDAS 4：一個(gè)用于研究污水處理廠細(xì)菌群落的全長(zhǎng)16S rRNA基因序列和分類法的全球目錄。

246.Modification of BRCA1-associated breast cancer risk by HMMR overexpression.

HMMR過(guò)量表達(dá)對(duì)BRCA1相關(guān)乳腺癌風(fēng)險(xiǎn)的修飾。

247.DNA methylation in newborns conceived by assisted reproductive technology.

通過(guò)輔助生殖技術(shù)孕育的新生兒的DNA甲基化。

248.Virally programmed extracellular vesicles sensitize cancer cells to oncolytic virus and small molecule therapy.

病毒編程的細(xì)胞外囊泡使癌細(xì)胞對(duì)溶瘤病毒和小分子療法敏感。

249.A universal deep neural network for in-depth cleaning of single-cell RNA-Seq data.

用于深入清理單細(xì)胞RNA-Seq數(shù)據(jù)的通用深度神經(jīng)網(wǎng)絡(luò)。

250.A genetic toolkit and gene switches to limit Mycoplasma growth for biosafety applications.

限制支原體生長(zhǎng)的遺傳工具箱和基因開關(guān)，用于生物安全應(yīng)用。

251.FGF21 is required for protein restriction to extend lifespan and improve metabolic health in male mice.

FGF21是蛋白質(zhì)限制延長(zhǎng)壽命和改善雄性小鼠代謝健康的必要條件。

252.A robust and interpretable machine learning approach using multimodal biological data to predict future pathological tau accumulation.

利用多模態(tài)生物數(shù)據(jù)預(yù)測(cè)未來(lái)病理性tau累積的穩(wěn)健和可解釋的機(jī)器學(xué)習(xí)方法。

253.Introducing principles of synaptic integration in the optimization of deep neural networks.

在深度神經(jīng)網(wǎng)絡(luò)的優(yōu)化中引入突觸整合的原則。

254.CHMP2A regulates tumor sensitivity to natural killer cell-mediated cytotoxicity.

CHMP2A調(diào)控腫瘤對(duì)自然殺傷細(xì)胞介導(dǎo)的細(xì)胞毒性的敏感性。

255.The overwhelming role of ballistic photons in ultrasonically guided light through tissue.

彈道光子在超聲引導(dǎo)下穿過(guò)組織的壓倒性作用。

256.CRISPR-mediated multiplexed live cell imaging of nonrepetitive genomic loci with one guide RNA per locus.

CRISPR介導(dǎo)的非重復(fù)性基因組位點(diǎn)的多重活細(xì)胞成像，每個(gè)位點(diǎn)只有一個(gè)引導(dǎo)RNA。

257.Phagosomal signalling of the C-type lectin receptor Dectin-1 is terminated by intramembrane proteolysis.

C型凝集素受體Dectin-1的吞噬體信號(hào)是由膜內(nèi)蛋白分解終止的。

258.Lupus enhancer risk variant causes dysregulation of IRF8 through cooperative lncRNA and DNA methylation machinery.

狼瘡增強(qiáng)器風(fēng)險(xiǎn)變體通過(guò)合作的lncRNA和DNA甲基化機(jī)制導(dǎo)致IRF8的失調(diào)。

259.Structural basis for PoxtA-mediated resistance to phenicol and oxazolidinone antibiotics.

PoxtA介導(dǎo)的對(duì)苯酚和噁唑烷酮類抗生素的抗性的結(jié)構(gòu)基礎(chǔ)。

260.Waffle Method: A general and flexible approach for improving throughput in FIB-milling.

華夫餅干法：?一種提高FIB研磨產(chǎn)量的通用和靈活的方法。

261.DNA sequence-dependent formation of heterochromatin nanodomains.

異染色質(zhì)納米域的DNA序列依賴性的形成。

262.Reply to: The overwhelming role of ballistic photons in ultrasonically guided light through tissue.

回應(yīng)：?彈道光子在超聲導(dǎo)引光穿過(guò)組織中的壓倒性作用。

263.DELE1 tracks perturbed protein import and processing in human mitochondria.

DELE1追蹤人類線粒體中擾亂的蛋白質(zhì)導(dǎo)入和處理。

264.Ca2+-activated sphingomyelin scrambling and turnover mediate ESCRT-independent lysosomal repair.

Ca2+激活的鞘磷脂擾動(dòng)和周轉(zhuǎn)介導(dǎo)ESCRT-獨(dú)立溶酶體修復(fù)。

265.Absolute measurement of cellular activities using photochromic single-fluorophore biosensors and intermittent quantification.

使用光致變色單螢光體生物傳感器和間歇性定量法絕對(duì)測(cè)量細(xì)胞活動(dòng)。

266.Elastic dosage compensation by X-chromosome upregulation.

通過(guò)X染色體上調(diào)進(jìn)行彈性劑量補(bǔ)償。

267.Zoonotic origin of the human malaria parasite Plasmodium malariae from African apes.

來(lái)自非洲猿猴的人類瘧疾寄生蟲瘧原蟲的人畜共通起源。

268.Activation of the essential kinase PDK1 by phosphoinositide-driven trans-autophosphorylation.

磷酸肌苷驅(qū)動(dòng)的反式自動(dòng)磷酸化激活基本激酶PDK1.

269.Enhancement of prime editing via xrRNA motif-joined pegRNA.

通過(guò)xrRNA主題連接的pegRNA增強(qiáng)質(zhì)粒編輯。

270.Mitochondrially targeted tamoxifen alleviates markers of obesity and type 2 diabetes mellitus in mice.

線粒體靶向他莫昔芬減輕小鼠肥胖和2型糖尿病的標(biāo)志物。

271.Citrullination of glucokinase is linked to autoimmune diabetes.

葡萄糖激酶的瓜氨酸化與自身免疫性糖尿病有關(guān)。

272.Predictive biomarkers for survival benefit with ramucirumab in urothelial cancer in the RANGE trial.

RANGE試驗(yàn)中拉莫西林單抗對(duì)尿道癌生存獲益的預(yù)測(cè)性生物標(biāo)志物。

273.Metal-responsive regulation of enzyme catalysis using genetically encoded chemical switches.

利用基因編碼的化學(xué)開關(guān)對(duì)酶的催化作用進(jìn)行金屬響應(yīng)性調(diào)節(jié)。

274.Depletion of tumor associated macrophages enhances local and systemic platelet-mediated anti-PD-1 delivery for post-surgery tumor recurrence treatment.

腫瘤相關(guān)巨噬細(xì)胞的耗盡增強(qiáng)了局部和全身血小板介導(dǎo)的抗PD-1輸送，用于手術(shù)后腫瘤復(fù)發(fā)治療。

275.Direct measurements of mRNA translation kinetics in living cells.

活細(xì)胞中mRNA翻譯動(dòng)力學(xué)的直接測(cè)量。

276.STAG2 regulates interferon signaling in melanoma via enhancer loop reprogramming.

STAG2通過(guò)增強(qiáng)子環(huán)路重編程調(diào)控黑色素瘤中的干擾素信號(hào)。

277.Cryo-EM structures of a LptDE transporter in complex with Pro-macrobodies offer insight into lipopolysaccharide translocation.

與Pro-macrobodies復(fù)合的LptDE轉(zhuǎn)運(yùn)體的低溫電鏡結(jié)構(gòu)提供了對(duì)脂多糖轉(zhuǎn)運(yùn)的深入了解。

278.Cell-intrinsic Aryl Hydrocarbon Receptor signalling is required for the resolution of injury-induced colonic stem cells.

細(xì)胞內(nèi)在的芳烴受體信號(hào)是解決損傷引起的結(jié)腸干細(xì)胞所必需的。

279.Efficient human-like antibody repertoire and hybridoma production in trans-chromosomic mice carrying megabase-sized human immunoglobulin loci.

攜帶百萬(wàn)堿基大小的人類免疫球蛋白基因組的反染色體小鼠高效的類人抗體復(fù)合物和雜交瘤生產(chǎn)。

280.Structural basis for the mechanisms of human presequence protease conformational switch and substrate recognition.

人類前序列蛋白酶的構(gòu)象轉(zhuǎn)換和底物識(shí)別機(jī)制的結(jié)構(gòu)基礎(chǔ)。

281.Neural structure of a sensory decoder for motor control.

用于運(yùn)動(dòng)控制的感覺(jué)解碼器的神經(jīng)結(jié)構(gòu)。

282.Structure-based design of stabilized recombinant influenza neuraminidase tetramers.

基于結(jié)構(gòu)設(shè)計(jì)的穩(wěn)定化重組流感神經(jīng)氨酸酶四聚體。

283.Structural basis for the SUMO protease activity of the atypical ubiquitin-specific protease USPL1.

非典型泛素特異性蛋白酶USPL1的SUMO蛋白酶活性的結(jié)構(gòu)基礎(chǔ)。

284.Mapping SP-C co-chaperone binding sites reveals molecular consequences of disease-causing mutations on protein maturation.

繪制SP-C協(xié)同伴侶的結(jié)合位點(diǎn)，揭示了致病突變對(duì)蛋白質(zhì)成熟的分子后果。

285.Group testing via hypergraph factorization applied to COVID-19.

應(yīng)用于COVID-19的超圖因子化的群體測(cè)試。

286.Integrative analysis of non-small cell lung cancer patient-derived xenografts identifies distinct proteotypes associated with patient outcomes.

對(duì)非小細(xì)胞肺癌患者異種移植的綜合分析確定了與患者預(yù)后相關(guān)的不同蛋白質(zhì)類型。

287.Multiomic profiling of the acute stress response in the mouse hippocampus.

小鼠海馬區(qū)急性應(yīng)激反應(yīng)的多組學(xué)分析。

288.acorde unravels functionally interpretable networks of isoform co-usage from single cell data.

acorde從單細(xì)胞數(shù)據(jù)中解讀了功能上可解釋的同構(gòu)體共同使用網(wǎng)絡(luò)。

289.In vivo base editing rescues cone photoreceptors in a mouse model of early-onset inherited retinal degeneration.

體內(nèi)堿基編輯挽救了早發(fā)遺傳性視網(wǎng)膜變性小鼠模型中的錐體光感受器。

290.Global field observations of tree die-off reveal hotter-drought fingerprint for Earth’s forests.

對(duì)樹木死亡的全球?qū)嵉赜^察揭示了地球森林更熱的干旱指紋。

291.Ultraviolet optical horn antennas for label-free detection of single proteins.

用于無(wú)標(biāo)簽檢測(cè)單一蛋白質(zhì)的紫外光角天線。

292.RNA aptamers specific for transmembrane p24 trafficking protein 6 and Clusterin for the targeted delivery of imaging reagents and RNA therapeutics to human β cells.

對(duì)跨膜p24販運(yùn)蛋白6和Clusterin有特異性的RNA誘導(dǎo)劑，用于定向輸送成像試劑和RNA治療劑到人類β細(xì)胞。

293.Auxiliary ATP binding sites support DNA unwinding by RecBCD.

輔助ATP結(jié)合位點(diǎn)支持RecBCD的DNA解旋。

294.SWI/SNF chromatin remodeler complex within the reward pathway is required for behavioral adaptations to stress.

獎(jiǎng)勵(lì)途徑中的SWI/SNF染色質(zhì)重塑器復(fù)合物是行為適應(yīng)壓力的必要條件。

295.Glutathione-dependent redox balance characterizes the distinct metabolic properties of follicular and marginal zone B cells.

谷胱甘肽依賴性氧化還原平衡描述了濾泡區(qū)和邊緣區(qū)B細(xì)胞的不同代謝特性。

296.Brain-wide mapping reveals that engrams for a single memory are distributed across multiple brain regions.

全腦圖譜顯示，單一記憶的engrams分布在多個(gè)腦區(qū)。

297.The engineered CD80 variant fusion therapeutic davoceticept combines checkpoint antagonism with conditional CD28 costimulation for anti-tumor immunity.

工程化的CD80變體融合療法davoceticept將檢查點(diǎn)拮抗與有條件的CD28成本刺激相結(jié)合，用于抗腫瘤免疫。

298.Astrocyte plasticity in mice ensures continued endfoot coverage of cerebral blood vessels following injury and declines with age.

小鼠星形細(xì)胞的可塑性確保了損傷后腦血管的持續(xù)內(nèi)足覆蓋，并隨年齡增長(zhǎng)而下降。

299.Neutralizing activity of BBIBP-CorV vaccine-elicited sera against Beta, Delta and other SARS-CoV-2 variants of concern.

300.Radiationless mechanism of UV deactivation by cuticle phenolics in plants.

301.The PripA-TbcrA complex-centered Rab GAP cascade facilitates macropinosome maturation in Dictyostelium.

302.Ensemble of nucleic acid absolute quantitation modules for copy number variation detection and RNA profiling.

303.Opposite physiological and pathological mTORC1-mediated roles of the CB1 receptor in regulating renal tubular function.

304.Loss of Rnf31 and Vps4b sensitizes pancreatic cancer to T cell-mediated killing.

305.Multilayered control of splicing regulatory networks by DAP3 leads to widespread alternative splicing changes in cancer.

306.Sirt6 reprograms myofibers to oxidative type through CREB-dependent Sox6 suppression.

307.Immunosuppressive niche engineering at the onset of human colorectal cancer.

FPR2在識(shí)別Aβ42和人參蛋白的神經(jīng)保護(hù)中的結(jié)構(gòu)基礎(chǔ)。

308.Exploration of the dynamic interplay between lipids and membrane proteins by hydrostatic pressure.

單細(xì)胞和空間分析揭示了結(jié)直腸癌中FAP+成纖維細(xì)胞和SPP1+巨噬細(xì)胞的互動(dòng)。

309.Deciphering spatial domains from spatially resolved transcriptomics with an adaptive graph attention auto-encoder.

BRG1缺失引起的非整倍體耐受性使染色體增加并恢復(fù)健康。

310.Current progress and open challenges for applying deep learning across the biosciences.

由MPK4和SUMM2介導(dǎo)的ROS平衡決定了協(xié)同細(xì)胞死亡。

311.The importance of biofilm formation for cultivation of a Micrarchaeon and its interactions with its Thermoplasmatales host.

生物膜形成對(duì)?Micrarchaeon?培養(yǎng)的重要性及其與其?Thermoplasmatales?宿主的相互作用。

312.Harnessing phosphonate antibiotics argolaphos biosynthesis enables a synthetic biology-based green synthesis of glyphosate.

利用膦酸鹽抗生素argolaphos?生物合成可以實(shí)現(xiàn)基于合成生物學(xué)的草甘膦綠色合成。

313.Discovery of a signaling feedback circuit that defines interferon responses in myeloproliferative neoplasms.

發(fā)現(xiàn)定義骨髓增生性腫瘤中干擾素反應(yīng)的信號(hào)反饋回路。

314.PI3Kγ stimulates a high molecular weight form of myosin light chain kinase to promote myeloid cell adhesion and tumor inflammation.

PI3Kγ?刺激一種高分子量形式的肌球蛋白輕鏈激酶，以促進(jìn)骨髓細(xì)胞粘附和腫瘤炎癥。

315.Long-chain ceramides are cell non-autonomous signals linking lipotoxicity to endoplasmic reticulum stress in skeletal muscle.

長(zhǎng)鏈神經(jīng)酰胺是將脂肪毒性與骨骼肌內(nèi)質(zhì)網(wǎng)應(yīng)激聯(lián)系起來(lái)的細(xì)胞非自主信號(hào)。

316.Biological invasions facilitate zoonotic disease emergences.

生物入侵促進(jìn)了人畜共患疾病的出現(xiàn)。

317.Structural basis of FPR2 in recognition of Aβ42 and neuroprotection by humanin.

FPR2?識(shí)別?Aβ42?和?humanin?神經(jīng)保護(hù)的結(jié)構(gòu)基礎(chǔ)。

318.Single-cell and spatial analysis reveal interaction of FAP+ fibroblasts and SPP1+ macrophages in colorectal cancer.

單細(xì)胞和空間分析揭示了結(jié)直腸癌中?FAP+?成纖維細(xì)胞和?SPP1+?巨噬細(xì)胞的相互作用。

319.Aneuploidy tolerance caused by BRG1 loss allows chromosome gains and recovery of fitness.

由?BRG1?丟失引起的非整倍體耐受允許染色體獲得和適應(yīng)性恢復(fù)。

320.ROS homeostasis mediated by MPK4 and SUMM2 determines synergid cell death.

由?MPK4?和?SUMM2?介導(dǎo)的?ROS?穩(wěn)態(tài)決定助細(xì)胞死亡。

321.Imaging vesicle formation dynamics supports the flexible model of clathrin-mediated endocytosis.

成像囊泡形成動(dòng)力學(xué)支持網(wǎng)格蛋白介導(dǎo)的內(nèi)吞作用的靈活模型。

322.Selective optogenetic control of Gq signaling using human Neuropsin.

使用人?Neuropsin?對(duì)?Gq?信號(hào)的選擇性光遺傳學(xué)控制。

323.Defining the early stages of intestinal colonisation by whipworms.

確定鞭蟲腸道定植的早期階段。

324.Quantitative phosphoproteomic analyses identify STK11IP as a lysosome-specific substrate of mTORC1 that regulates lysosomal acidification.

定量磷酸化蛋白質(zhì)組學(xué)分析將?STK11IP?鑒定為?mTORC1?的溶酶體特異性底物，可調(diào)節(jié)溶酶體酸化。

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